BMRB Entry 31219

Name: Solution structure of alpha conotoxin LvID
Published: 2025-04-15

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PDB ID: 9eh4
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR31219
MolProbity Validation Chart

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of alpha conotoxin LvID

Deposition date:

2024-11-22

Original release date:

2025-04-15

Authors:

Harvey, P.; Craik, D.

Citation:

Citation: Guo, M.; Zhu, X.; Ma, T.; Xu, C.; Zhangsun, D.; Yu, J.; Kaas, Q.; Harvey, P.; McIntosh, J.; Craik, D.; Luo, S.. "Selective Inhibition of Rat alpha7 Nicotinic Acetylcholine Receptors by LvID, a Newly Characterized alpha4/7-Conotoxin from Conus lividus" J. Med. Chem. ., .-. (2025).
PubMed: 40205658

Assembly members:

Assembly members:
entity_1, polymer, 17 residues, 1748.011 Da.

Natural source:

Natural source: Common Name: Conus lividus Taxonomy ID: 89426 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Conus lividus

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: DCCSEPPCILQNPDICX

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	49
15N chemical shifts	12
1H chemical shifts	97

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	unit_1	1

Entities:

Entity 1, unit_1 17 residues - 1748.011 Da.

1

ASP

CYS

SER

GLU

PRO

CYS

ILE

LEU

2

GLN

ASN

PRO

ASP

ILE

CYS

NH2

Samples:

sample_1: LvID 1.0 mM

sample_conditions_1: pH: 3.0; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D TOCSY	sample_1	isotropic	sample_conditions_1
2D NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_1	isotropic	sample_conditions_1

Software:

TopSpin, Bruker Biospin - processing

CcpNmr Analysis, CCPN - chemical shift assignment

CYANA, Guntert, Mumenthaler and Wuthrich - structure calculation

CNS, Brunger, Adams, Clore, Gros, Nilges and Read - refinement

NMR spectrometers:

Bruker AVANCE III HD 600 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks