BMRB Entry 31076

Name: Taipan Natriuretic Peptide C -TNPc
Published: 2023-04-10

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PDB ID: 8s9y
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR31076
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Taipan Natriuretic Peptide C -TNPc

Deposition date:

2023-03-30

Original release date:

2023-04-10

Authors:

Torres, A.; Alewood, P.

Citation:

Citation: Vink, Simone; Akondi, Kalyana; Jin, Jean; Poth, Kim; Torres, Allan; Kuchel, Philip; Burke, Sandra; Head, Geoffrey; Alewood, Paul. "Taipan Natriuretic Peptides Are Potent and Selective Agonists for the Natriuretic Peptide Receptor A" Molecules 28, 3063-3063 (2023).

Assembly members:

Assembly members:
entity_1, polymer, 39 residues, 4119.686 Da.

Natural source:

Natural source: Common Name: Oxyuranus microlepidotus Taxonomy ID: 111177 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Oxyuranus microlepidotus

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: SDSKIGNGCFGFPLDRIGSV SGLGCNRIMQNPPKKFSGE

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
1H chemical shifts	193

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	unit_1	1

Entities:

Entity 1, unit_1 39 residues - 4119.686 Da.

1

SER

ASP

SER

LYS

ILE

GLY

ASN

GLY

CYS

PHE

2

GLY

PHE

PRO

LEU

ASP

ARG

ILE

GLY

SER

VAL

3

SER

GLY

LEU

GLY

CYS

ASN

ARG

ILE

MET

GLN

4

ASN

PRO

LYS

PHE

SER

GLY

GLU

Samples:

sample_1: Taipan Natriuetic Peptide C -TNPc 1 mM

sample_conditions_1: pH: 4.4; pressure: 1 atm; temperature: 313 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D DQF-COSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1

Software:

CNS, Brunger, Adams, Clore, Gros, Nilges and Read - refinement

DYANA, Guntert, Braun and Wuthrich - structure calculation

XEASY, Bartels et al. - chemical shift assignment, peak picking

NMR spectrometers:

Bruker DMX 600 MHz