BMRB Entry 30910

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PDB ID: 7mzw
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR30910
MolProbity Validation Chart

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Title:
Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025
Deposition date:
2021-05-24
Original release date:
2021-12-03
Authors:
Rossi, P.; Sowaileh, M.; Reshetnyak, A.; Kalodimos, C.
Citation:

Citation: Reshetnyak, A.; Rossi, P.; Myasnikov, A.; Sowaileh, M.; Mohanty, J.; Nourse, A.; Miller, D.; Lax, I.; Schlessinger, J.; Kalodimos, C.. "Mechanism for the activation of the anaplastic lymphoma kinase receptor"  Nature 600, 153-157 (2021).
PubMed: 34819673

Assembly members:

Assembly members:
entity_1, polymer, 353 residues, 36452.293 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli BL21(DE3)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: QTPIFDPTVHWLFTTCGASG PHGPTQAQCNNAYQNSNLSV EVGSEGPLKGIQIWKVPATD TYSISGYGAAGGKGGKNTMM RSHGVSVLGIFNLEKDDMLY ILVGQQGEDACPSTNQLIQK VCIGENNVIEEEIRVNRSVH EWAGGGGGGGGATYVFKMKD GVPVPLIIAAGGGGRAYGAK TDTFHPERLENNSSVLGLNG NSGAAGGGGGWNDNTSLLWA GKSLQEGATGGHSCPQAMKK WGWETRGGFGGGGGGCSSGG GGGGYIGGNAASNNDPEMDG EDGVSFISPLGILYTPALKV MEGHGEVNIKHYLNCSHCEV DECHMDPESHKVICFCDHGT VLAEDGVSCIVSP

Data sets:
Data typeCount
13C chemical shifts1098
15N chemical shifts323
1H chemical shifts810

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11

Entities:

Entity 1, unit_1 353 residues - 36452.293 Da.

1   GLNTHRPROILEPHEASPPROTHRVALHIS
2   TRPLEUPHETHRTHRCYSGLYALASERGLY
3   PROHISGLYPROTHRGLNALAGLNCYSASN
4   ASNALATYRGLNASNSERASNLEUSERVAL
5   GLUVALGLYSERGLUGLYPROLEULYSGLY
6   ILEGLNILETRPLYSVALPROALATHRASP
7   THRTYRSERILESERGLYTYRGLYALAALA
8   GLYGLYLYSGLYGLYLYSASNTHRMETMET
9   ARGSERHISGLYVALSERVALLEUGLYILE
10   PHEASNLEUGLULYSASPASPMETLEUTYR
11   ILELEUVALGLYGLNGLNGLYGLUASPALA
12   CYSPROSERTHRASNGLNLEUILEGLNLYS
13   VALCYSILEGLYGLUASNASNVALILEGLU
14   GLUGLUILEARGVALASNARGSERVALHIS
15   GLUTRPALAGLYGLYGLYGLYGLYGLYGLY
16   GLYALATHRTYRVALPHELYSMETLYSASP
17   GLYVALPROVALPROLEUILEILEALAALA
18   GLYGLYGLYGLYARGALATYRGLYALALYS
19   THRASPTHRPHEHISPROGLUARGLEUGLU
20   ASNASNSERSERVALLEUGLYLEUASNGLY
21   ASNSERGLYALAALAGLYGLYGLYGLYGLY
22   TRPASNASPASNTHRSERLEULEUTRPALA
23   GLYLYSSERLEUGLNGLUGLYALATHRGLY
24   GLYHISSERCYSPROGLNALAMETLYSLYS
25   TRPGLYTRPGLUTHRARGGLYGLYPHEGLY
26   GLYGLYGLYGLYGLYCYSSERSERGLYGLY
27   GLYGLYGLYGLYTYRILEGLYGLYASNALA
28   ALASERASNASNASPPROGLUMETASPGLY
29   GLUASPGLYVALSERPHEILESERPROLEU
30   GLYILELEUTYRTHRPROALALEULYSVAL
31   METGLUGLYHISGLYGLUVALASNILELYS
32   HISTYRLEUASNCYSSERHISCYSGLUVAL
33   ASPGLUCYSHISMETASPPROGLUSERHIS
34   LYSVALILECYSPHECYSASPHISGLYTHR
35   VALLEUALAGLUASPGLYVALSERCYSILE
36   VALSERPRO

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