BMRB Entry 27711

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR27711

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Title:
Chemical shifts of calmodulin C-terminal lobe in complex with KN-93
Deposition date:
2018-12-04
Original release date:
2019-02-11
Authors:
Vlach, Jiri; Saad, Jamil
Citation:

Citation: Wong, Melanie; Samal, Alexandra; Lee, Mike; Vlach, Jiri; Novikov, Nikolai; Niedziela-Majka, Anita; Feng, Joy; Koltun, Dmitry; Brendza, Katherine; Kwon, Hyock Joo; Schultz, Brian; Sakowicz, Roman; Saad, Jamil; Papalia, Giuseppe. "The KN-93 Molecule Inhibits Calcium/Calmodulin-Dependent Protein Kinase II (CaMKII) Activity by Binding to Ca"  J. Mol. Biol. 431, 1440-1459 (2019).
PubMed: 30753871

Assembly members:

Assembly members:
CaM-C, polymer, 73 residues, 8395.0952 Da.
CALCIUM ION, non-polymer, 40.078 Da.

Natural source:

Natural source:   Common Name: Rat   Taxonomy ID: 10116   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Rattus norvegicus

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET28

Entity Sequences (FASTA):

Entity Sequences (FASTA):
CaM-C: MKDTDSEEEIREAFRVFDKD GNGYISAAELRHVMTNLGEK LTDEEVDEMIREADIDGDGQ VNYEEFVQMMTAK

Data sets:
Data typeCount
13C chemical shifts139
15N chemical shifts71
1H chemical shifts71

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1CaM-C1
2Ca2

Entities:

Entity 1, CaM-C 73 residues - 8395.0952 Da.

1   METLYSASPTHRASPSERGLUGLUGLUILE
2   ARGGLUALAPHEARGVALPHEASPLYSASP
3   GLYASNGLYTYRILESERALAALAGLULEU
4   ARGHISVALMETTHRASNLEUGLYGLULYS
5   LEUTHRASPGLUGLUVALASPGLUMETILE
6   ARGGLUALAASPILEASPGLYASPGLYGLN
7   VALASNTYRGLUGLUPHEVALGLNMETMET
8   THRALALYS

Entity 2, Ca - Ca - 40.078 Da.

1   CA

Related Database Links:

GenBank AAA40864.1

Download HSQC peak lists in one of the following formats:
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SPARKY: Backbone or all simulated peaks