BMRB Entry 27478

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR27478

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Title:
Structural studies suggest aggregation as one of the modes of action for teixobactin
Deposition date:
2018-05-14
Original release date:
2018-09-20
Authors:
Oster, Carl; Lewandowski, Jozef
Citation:

Citation: Oster, Carl; Walkowiak, Grzegorz; Hughes, Dallas; Spoering, Amy; Peoples, Aaron; Catherwood, Anita; Tod, Julie; Lloyd, Adrian; Herrmann, Torsten; Lewis, Kim; Dowson, Christopher; Lewandowski, Jozef. "Structural studies suggest aggregation as one of the modes of action for teixobactin."  Chem. Sci. 9, 8850-8859 (2018).
PubMed: 30627403

Assembly members:

Assembly members:
teixobactin, polymer, 11 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Eleftheria terrae   Taxonomy ID: 1597781   Superkingdom: Bacteria   Kingdom: not available   Genus/species: Eleftheria terrae

Experimental source:

Experimental source:   Production method: purified from the natural source   Host organism: Eleftheria terrae   Vector: -

Entity Sequences (FASTA):

Entity Sequences (FASTA):
teixobactin: XISXXISXAXI

Data sets:
Data typeCount
13C chemical shifts42
15N chemical shifts12
1H chemical shifts80

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1teixobactin1

Entities:

Entity 1, teixobactin 11 residues - Formula weight is not available

1   ZAEILESERDGN28JILESERDTHALAXXX
2   ILE

Samples:

sample_1: teixobactin mM; sodium phosphate 10 mM; DPC, [U-99% 2H], 150 mM

sample_conditions_1: ionic strength: 0.014 M; pH: 6.5; pressure: 1 atm; temperature: 273 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-15N HSQCsample_1isotropicsample_conditions_1
2D 1H-13C HSQCsample_1isotropicsample_conditions_1
3D HCCH-TOCSYsample_1isotropicsample_conditions_1
3D HNCACBsample_1isotropicsample_conditions_1
3D CBCA(CO)NHsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H COSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1
3D 1H-15N NOESYsample_1isotropicsample_conditions_1

Software:

SPARKY, Goddard - chemical shift assignment

NMR spectrometers:

  • Bruker Avance 700 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks