BMRB Entry 25466

Name: BCL-XL
Published: 2017-08-02

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR25466

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

BCL-XL

Deposition date:

2015-02-04

Original release date:

2017-08-02

Authors:

Yao, Yong; Marassi, Francesca

Citation:

Citation: Yao, Yong; Fujimoto, Lynn; Hirshman, Nathan; Bobkov, Andrey; Antignani, Antonella; Youle, Richard; Marassi, Francesca. "Conformation of BCL-XL upon Membrane Integration." J. Mol. Biol. 427, 2262-2270 (2015).
PubMed: 25731750

Assembly members:

Assembly members:
BCL-XL, polymer, 205 residues, Formula weight is not available

Natural source:

Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pETshin

Entity Sequences (FASTA):

Entity Sequences (FASTA):
BCL-XL: MAHHHHHHGSPEFMSQSNRE LVVDFLSYKLSQKGYSWSQF SDVEENRTEAPEGTESAVKQ ALREAGDEFELRYRRAFSDL TSQLHITPGTAYQSFEQVVN ELFRDGVNWGRIVAFFSFGG ALCVESVDKEMQVLVSRIAA WMATYLNDHLEPWIQENGGW DTFVELYGNNAAAESRKGQE RFNRWFLTGMTVAGVVLLGS LFSRK

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	295
15N chemical shifts	150
1H chemical shifts	150

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	BCL-XL	1

Entities:

Entity 1, BCL-XL 205 residues - Formula weight is not available

1

MET

ALA

HIS

GLY

SER

2

PRO

GLU

PHE

MET

SER

GLN

SER

ASN

ARG

GLU

3

LEU

VAL

ASP

PHE

LEU

SER

TYR

LYS

LEU

4

SER

GLN

LYS

GLY

TYR

SER

TRP

SER

GLN

PHE

5

SER

ASP

VAL

GLU

ASN

ARG

THR

GLU

ALA

6

PRO

GLU

GLY

THR

GLU

SER

ALA

VAL

LYS

GLN

7

ALA

LEU

ARG

GLU

ALA

GLY

ASP

GLU

PHE

GLU

8

LEU

ARG

TYR

ARG

ALA

PHE

SER

ASP

LEU

9

THR

SER

GLN

LEU

HIS

ILE

THR

PRO

GLY

THR

10

ALA

TYR

GLN

SER

PHE

GLU

GLN

VAL

ASN

11

GLU

LEU

PHE

ARG

ASP

GLY

VAL

ASN

TRP

GLY

12

ARG

ILE

VAL

ALA

PHE

SER

PHE

GLY

13

ALA

LEU

CYS

VAL

GLU

SER

VAL

ASP

LYS

GLU

14

MET

GLN

VAL

LEU

VAL

SER

ARG

ILE

ALA

15

TRP

MET

ALA

THR

TYR

LEU

ASN

ASP

HIS

LEU

16

GLU

PRO

TRP

ILE

GLN

GLU

ASN

GLY

TRP

17

ASP

THR

PHE

VAL

GLU

LEU

TYR

GLY

ASN

18

ALA

GLU

SER

ARG

LYS

GLY

GLN

GLU

19

ARG

PHE

ASN

ARG

TRP

PHE

LEU

THR

GLY

MET

20

THR

VAL

ALA

GLY

VAL

LEU

GLY

SER

21

LEU

PHE

SER

ARG

LYS

Samples:

sample_1: BCL-XL, [U-99% 13C; U-99% 15N], 0.1 mM; H20 90%; D20 10%

sample_conditions_1: ionic strength: 0.025 M; pH: 6.8; pressure: 1 atm; temperature: 273 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1

Software:

TOPSPIN, Bruker Biospin - collection

NMR spectrometers:

Bruker Avance 600 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks