BMRB Entry 25377

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PDB ID: 2mwy
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR25377
MolProbity Validation Chart

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Title:
MDMX-P53
Deposition date:
2014-12-03
Original release date:
2016-01-25
Authors:
Grace, Christy
Citation:

Citation: Grace, Christy; Kriwacki, Richard; Ban, David. "Monitoring ligand induced protein ordering in drug discovery"  J. Mol. Biol. ., .-..

Assembly members:

Assembly members:
entity_1, polymer, 89 residues, 10160.976 Da.
entity_2, polymer, 15 residues, 1807.993 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: BL21(DE3)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: QINQVRPKLPLLKILHAAGA QGEMFTVKEVMHYLGQYIMV KQLYDQQEQHMVYCGGDLLG ELLGRQSFSVKDPSPLYDML RKNLVTLAT
entity_2: SQETFSDLWKLLPEN

Data sets:
Data typeCount
1H chemical shifts585

Additional metadata:

  • Assembly
  • Samples and Experiments
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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11
2entity_22

Entities:

Entity 1, entity_1 89 residues - 10160.976 Da.

Residue 1 corresponds to 23 in MDMX

1   GLNILEASNGLNVALARGPROLYSLEUPRO
2   LEULEULYSILELEUHISALAALAGLYALA
3   GLNGLYGLUMETPHETHRVALLYSGLUVAL
4   METHISTYRLEUGLYGLNTYRILEMETVAL
5   LYSGLNLEUTYRASPGLNGLNGLUGLNHIS
6   METVALTYRCYSGLYGLYASPLEULEUGLY
7   GLULEULEUGLYARGGLNSERPHESERVAL
8   LYSASPPROSERPROLEUTYRASPMETLEU
9   ARGLYSASNLEUVALTHRLEUALATHR

Entity 2, entity_2 15 residues - 1807.993 Da.

Peptide is TAD of p53 from 15 to 29

1   SERGLNGLUTHRPHESERASPLEUTRPLYS
2   LEULEUPROGLUASN