BMRB Entry 21060

Name: conotoxin Eb1.6
Published: 2022-03-01

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR21060

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

conotoxin Eb1.6

Deposition date:

2015-12-17

Original release date:

2022-03-01

Authors:

Jiang, Ling; Du, Tianpeng

Citation:

Citation: Liu, Zhuguo; Bartels, Peter; Sadeghi, Mahsa; Du, Tianpeng; Dai, Qing; Zhu, Cui; Yu, Shuo; Wang, Shuo; Dong, Mingxin; Sun, Ting; Guo, Jiabin; Peng, Shuangqing; Jiang, Ling; Adams, David; Dai, Qiuyun. "A novel alpha-conopeptide Eu1.6 inhibits N-type (Ca V 2.2) calcium channels and exhibits potent analgesic activity" Sci. Rep. 8, 1004-1004 (2018).
PubMed: 29343689

Assembly members:

Assembly members:
entity, polymer, 16 residues, 1669.013 Da.

Natural source:

Natural source: Common Name: Conus eburneus Taxonomy ID: 101300 Superkingdom: Eukaryiota Kingdom: Metazoa Genus/species: Conus eburneus

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: GCCSNPACMLKNPNLC

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
1H chemical shifts	91

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	Eb1.6	1

Entities:

Entity 1, Eb1.6 16 residues - 1669.013 Da.

1

GLY

CYS

SER

ASN

PRO

ALA

CYS

MET

LEU

2

LYS

ASN

PRO

ASN

LEU

CYS

Samples:

sample_1: entity 0.5 mM; phosphate buffer 20 mM; H2O 90%; D2O, [U-2H], 10%

sample_conditions_1: pH: 5.5; temperature: 303 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D DQF-COSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1

Software:

CYANA, Guntert, Mumenthaler and Wuthrich - structure solution

NMRPipe, Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax - processing

XEASY, Bartels et al. - chemical shift assignment, data analysis

NMR spectrometers:

Bruker Avance 800 MHz