Biological Magnetic Resonance Data Bank

A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 20116

Title: Substance P in DMPC:CHAPS q=0.25 bicelles   PubMed: 20937248

Deposition date: 2009-12-31 Original release date: 2010-10-27

Authors: Gayen, Anindita; Mukhopadhyay, Chaitali

Citation: Gayen, Anindita; Goswami, Sudipto Kishore; Mukhopadhyay, Chaitali. "NMR evidence of GM1-induced conformational change of Substance P using isotropic bicelles."  Biochim. Biophys. Acta 1808, 127-139 (2011).

Assembly members:
Substance_P, polymer, 11 residues, Formula weight is not available

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):

Data sets:
Data typeCount
1H chemical shifts88

Additional metadata:

  • Assembly
  • Samples and Experiments
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Entity Assembly IDEntity NameEntity ID
1Substance P1


Entity 1, Substance P 11 residues - Formula weight is not available

2   MET


Substance_P_in_bicelle: Substance P 3.7 mM; DMPC/CHAPS bicelles 92.5 mM; H2O mM

bicellar_solution: pH: 5.5; pressure: 1 atm; temperature: 298 K


NameSampleSample stateSample conditions
2D 1H-1H TOCSYSubstance_P_in_bicelleisotropicbicellar_solution
2D 1H-1H NOESYSubstance_P_in_bicelleisotropicbicellar_solution
2D DQF-COSYSubstance_P_in_bicelleisotropicbicellar_solution


X-PLOR NIH, Charles Schwieters - refinement, structure solution

NMR spectrometers:

  • Bruker DRX 500 MHz