BMRB Entry 19562

Name: NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB
Published: 2014-02-12

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PDB ID: 2mfq
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19562
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR solution structures of FRS2a PTB domain with neurotrophin receptor TrkB

Deposition date:

2013-10-18

Original release date:

2014-02-12

Authors:

Zeng, Lei; Zhou, Ming-Ming

Citation:

Citation: Zeng, Lei; Kuti, Miklos; Mujtaba, Shiraz; Zhou, Ming-Ming. "Structural insights into FRS2 PTB domain recognition by neurotrophin receptor TrkB." Proteins 82, 1534-1541 (2014).
PubMed: 24470253

Assembly members:

Assembly members:
entity_1, polymer, 115 residues, 13441.146 Da.
entity_2, polymer, 24 residues, 2553.905 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET28b, pGEX 4T1

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: SHMDTVPDNHRNKFKVINVD DDGNELGSGIMELTDTELIL YTRKRDSVKWHYLCLRRYGY DSNLFSFESGRRCQTGQGIF AFKCARAEELFNMLQEIMQN NSINVVEEPVVERNN
entity_2: GGPDAVIIGMTKIPVIENPQ XFGI

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	419
15N chemical shifts	134
1H chemical shifts	862

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	FRS2a PTB domain	1
2	neurotrophin receptor TrkB	2

Entities:

Entity 1, FRS2a PTB domain 115 residues - 13441.146 Da.

1

SER

HIS

MET

ASP

THR

VAL

PRO

ASP

ASN

HIS

2

ARG

ASN

LYS

PHE

LYS

VAL

ILE

ASN

VAL

ASP

3

ASP

GLY

ASN

GLU

LEU

GLY

SER

GLY

ILE

4

MET

GLU

LEU

THR

ASP

THR

GLU

LEU

ILE

LEU

5

TYR

THR

ARG

LYS

ARG

ASP

SER

VAL

LYS

TRP

6

HIS

TYR

LEU

CYS

LEU

ARG

TYR

GLY

TYR

7

ASP

SER

ASN

LEU

PHE

SER

PHE

GLU

SER

GLY

8

ARG

CYS

GLN

THR

GLY

GLN

GLY

ILE

PHE

9

ALA

PHE

LYS

CYS

ALA

ARG

ALA

GLU

LEU

10

PHE

ASN

MET

LEU

GLN

GLU

ILE

MET

GLN

ASN

11

ASN

SER

ILE

ASN

VAL

GLU

PRO

VAL

12

VAL

GLU

ARG

ASN

Entity 2, neurotrophin receptor TrkB 24 residues - 2553.905 Da.

1

GLY

PRO

ASP

ALA

VAL

ILE

GLY

MET

2

THR

LYS

ILE

PRO

VAL

ILE

GLU

ASN

PRO

GLN

3

PTR

PHE

GLY

ILE

Name	Sample	Sample state	Sample conditions
3D HNCACB	sample_2	isotropic	sample_conditions_1
3D HNz(CO)CACB	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-15N TOCSY	sample_2	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_1	isotropic	sample_conditions_1
3D 13C-edited 13C/15N-filtered NOESY	sample_1	isotropic	sample_conditions_1

PDB	1XR0 2MFQ 2MFQ
DBJ	BAC26132 BAG35381 BAI45690
GB	AAB92554 AAH21562 AAH43109 AAH55334 ABY87531
REF	NP_001036020 NP_001101567 NP_001186555 NP_001230138 NP_001265280
SP	Q8C180 Q8WU20
TPG	DAA29812
AlphaFold	Q8C180 Q8WU20

BMRB Entry 19562

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

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