BMRB Entry 19126

Name: Structure of full-length transmembrane domains of human glycine receptor 1 monomer subunit
Published: 2013-09-03

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PDB ID: 2m6b
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19126
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Structure of full-length transmembrane domains of human glycine receptor 1 monomer subunit

Deposition date:

2013-03-28

Original release date:

2013-09-03

Authors:

Mowrey, David; Cui, Tanxing; Jia, Yuanyuan; Ma, Dejian; Makhov, Alexander; Zhang, Peijun; Tang, Pei; Xu, Yan

Citation:

Citation: Mowrey, David; Cui, Tanxing; Jia, Yuanyuan; Ma, Dejian; Makhov, Alexander; Zhang, Peijun; Tang, Pei; Xu, Yan. "Open-Channel Structures of the Human Glycine Receptor 1 Full-Length Transmembrane Domain." Structure 21, 1897-1904 (2013).
PubMed: 23994010

Assembly members:

Assembly members:
GlyR, polymer, 150 residues, 17320.490 Da.

Natural source:

Natural source: Common Name: Humans Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET-31b(+)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
GlyR: MLERQLGYYLIQLYIPSLLI VILSWISFWINLDAAPARVG LGITTVLTLTTQSSGSRASL PKVSYVKAIDIWLAVCLLFV FSALLEYAAVNFVSRQREFG GGGFIQRAKKIDKISRIGFP LAFLIFNLFYWIIYKIVRRE DEFEHHHHHH

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	283
15N chemical shifts	155
1H chemical shifts	707

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	GlyR	1

Entities:

Entity 1, GlyR 150 residues - 17320.490 Da.

1	MET	LEU	GLU	ARG	GLN	LEU	GLY	TYR	TYR	LEU
2	ILE	GLN	LEU	TYR	ILE	PRO	SER	LEU	LEU	ILE
3	VAL	ILE	LEU	SER	TRP	ILE	SER	PHE	TRP	ILE
4	ASN	LEU	ASP	ALA	ALA	PRO	ALA	ARG	VAL	GLY
5	LEU	GLY	ILE	THR	THR	VAL	LEU	THR	LEU	THR
6	THR	GLN	SER	SER	GLY	SER	ARG	ALA	SER	LEU
7	PRO	LYS	VAL	SER	TYR	VAL	LYS	ALA	ILE	ASP
8	ILE	TRP	LEU	ALA	VAL	CYS	LEU	LEU	PHE	VAL
9	PHE	SER	ALA	LEU	LEU	GLU	TYR	ALA	ALA	VAL
10	ASN	PHE	VAL	SER	ARG	GLN	ARG	GLU	PHE	GLY
11	GLY	GLY	GLY	PHE	ILE	GLN	ARG	ALA	LYS	LYS
12	ILE	ASP	LYS	ILE	SER	ARG	ILE	GLY	PHE	PRO
13	LEU	ALA	PHE	LEU	ILE	PHE	ASN	LEU	PHE	TYR
14	TRP	ILE	ILE	TYR	LYS	ILE	VAL	ARG	ARG	GLU
15	ASP	GLU	PHE	GLU	HIS	HIS	HIS	HIS	HIS	HIS

Name	Sample	Sample state	Sample conditions
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_2	isotropic	sample_conditions_1
3D HNCO	sample_2	isotropic	sample_conditions_1
3D HNCA	sample_2	isotropic	sample_conditions_1
3D HN(CO)CA	sample_2	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_2	isotropic	sample_conditions_1
3D HNCACB	sample_2	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1

BMRB Entry 19126

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	MET	LEU	GLU	ARG	GLN	LEU	GLY	TYR	TYR	LEU
2	ILE	GLN	LEU	TYR	ILE	PRO	SER	LEU	LEU	ILE
3	VAL	ILE	LEU	SER	TRP	ILE	SER	PHE	TRP	ILE
4	ASN	LEU	ASP	ALA	ALA	PRO	ALA	ARG	VAL	GLY
5	LEU	GLY	ILE	THR	THR	VAL	LEU	THR	LEU	THR
6	THR	GLN	SER	SER	GLY	SER	ARG	ALA	SER	LEU
7	PRO	LYS	VAL	SER	TYR	VAL	LYS	ALA	ILE	ASP
8	ILE	TRP	LEU	ALA	VAL	CYS	LEU	LEU	PHE	VAL
9	PHE	SER	ALA	LEU	LEU	GLU	TYR	ALA	ALA	VAL
10	ASN	PHE	VAL	SER	ARG	GLN	ARG	GLU	PHE	GLY
11	GLY	GLY	GLY	PHE	ILE	GLN	ARG	ALA	LYS	LYS
12	ILE	ASP	LYS	ILE	SER	ARG	ILE	GLY	PHE	PRO
13	LEU	ALA	PHE	LEU	ILE	PHE	ASN	LEU	PHE	TYR
14	TRP	ILE	ILE	TYR	LYS	ILE	VAL	ARG	ARG	GLU
15	ASP	GLU	PHE	GLU	HIS	HIS	HIS	HIS	HIS	HIS

1	MET	LEU	GLU	ARG	GLN	LEU	GLY	TYR	TYR	LEU
2	ILE	GLN	LEU	TYR	ILE	PRO	SER	LEU	LEU	ILE
3	VAL	ILE	LEU	SER	TRP	ILE	SER	PHE	TRP	ILE
4	ASN	LEU	ASP	ALA	ALA	PRO	ALA	ARG	VAL	GLY
5	LEU	GLY	ILE	THR	THR	VAL	LEU	THR	LEU	THR
6	THR	GLN	SER	SER	GLY	SER	ARG	ALA	SER	LEU
7	PRO	LYS	VAL	SER	TYR	VAL	LYS	ALA	ILE	ASP
8	ILE	TRP	LEU	ALA	VAL	CYS	LEU	LEU	PHE	VAL
9	PHE	SER	ALA	LEU	LEU	GLU	TYR	ALA	ALA	VAL
10	ASN	PHE	VAL	SER	ARG	GLN	ARG	GLU	PHE	GLY
11	GLY	GLY	GLY	PHE	ILE	GLN	ARG	ALA	LYS	LYS
12	ILE	ASP	LYS	ILE	SER	ARG	ILE	GLY	PHE	PRO
13	LEU	ALA	PHE	LEU	ILE	PHE	ASN	LEU	PHE	TYR
14	TRP	ILE	ILE	TYR	LYS	ILE	VAL	ARG	ARG	GLU
15	ASP	GLU	PHE	GLU	HIS	HIS	HIS	HIS	HIS	HIS

1	MET	LEU	GLU	ARG	GLN	LEU	GLY	TYR	TYR	LEU
2	ILE	GLN	LEU	TYR	ILE	PRO	SER	LEU	LEU	ILE
3	VAL	ILE	LEU	SER	TRP	ILE	SER	PHE	TRP	ILE
4	ASN	LEU	ASP	ALA	ALA	PRO	ALA	ARG	VAL	GLY
5	LEU	GLY	ILE	THR	THR	VAL	LEU	THR	LEU	THR
6	THR	GLN	SER	SER	GLY	SER	ARG	ALA	SER	LEU
7	PRO	LYS	VAL	SER	TYR	VAL	LYS	ALA	ILE	ASP
8	ILE	TRP	LEU	ALA	VAL	CYS	LEU	LEU	PHE	VAL
9	PHE	SER	ALA	LEU	LEU	GLU	TYR	ALA	ALA	VAL
10	ASN	PHE	VAL	SER	ARG	GLN	ARG	GLU	PHE	GLY
11	GLY	GLY	GLY	PHE	ILE	GLN	ARG	ALA	LYS	LYS
12	ILE	ASP	LYS	ILE	SER	ARG	ILE	GLY	PHE	PRO
13	LEU	ALA	PHE	LEU	ILE	PHE	ASN	LEU	PHE	TYR
14	TRP	ILE	ILE	TYR	LYS	ILE	VAL	ARG	ARG	GLU
15	ASP	GLU	PHE	GLU	HIS	HIS	HIS	HIS	HIS	HIS