BMRB Entry 19112

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR19112

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Title:
Structural characterization by NMR of a double phosphorylated chimeric peptide vaccine for treatment of Alzheimer's disease
Deposition date:
2013-03-27
Original release date:
2013-05-03
Authors:
Matzapetakis, Manolis; Ramirez-Gualito, Karla; Richter, Monique; Berger, Stefan; Singer, David
Citation:

Citation: Ramirez-Gualito, Karla; Richter, Monique; Matzapetakis, Manolis; Singer, David; Berger, Stefan. "Structural characterization by NMR of a double phosphorylated chimeric Peptide vaccine for treatment of Alzheimer's disease"  Molecules 18, 4929-4941 (2013).
PubMed: 23624647

Assembly members:

Assembly members:
TAU231, polymer, 28 residues, 2984.9 Da.

Natural source:

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
TAU231: QDAYNAGGGHNGVFDGPSLV RXPPKXPS

Data sets:
Data typeCount
13C chemical shifts66
15N chemical shifts20
1H chemical shifts113

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1TAU2311

Entities:

Entity 1, TAU231 28 residues - 2984.9 Da.

1   GLNASPALATYRASNALAGLYGLYGLYHIS
2   ASNGLYVALPHEASPGLYPROSERLEUVAL
3   ARGTPOPROPROLYSSEPPROSER

Samples:

sample: TAU231 1 mM; D2O 10%; DSS 0.1 mM; sodium phosphate 200 mM

sample_conditions_1: ionic strength: 0.2 M; pH: 5.8; pressure: 1 atm; temperature: 300 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-15N HSQCsampleisotropicsample_conditions_1
2D DQF-COSYsampleisotropicsample_conditions_1
2D 1H-1H NOESYsampleisotropicsample_conditions_1
2D 1H-1H TOCSYsampleisotropicsample_conditions_1
2D 1H-1H ROESYsampleisotropicsample_conditions_1
2D 1H-13C HSQCsampleisotropicsample_conditions_1
2D 1H-13C HMBCsampleisotropicsample_conditions_1

Software:

ANALYSIS v2.2, CCPN - chemical shift assignment

NMR spectrometers:

  • Bruker Avance 700 MHz
  • Bruker Avance 800 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks