BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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BMRB Entry 18793

Title: Solution structure of BCL-xL in complex with PUMA BH3 peptide   PubMed: 23340338

Deposition date: 2012-10-19 Original release date: 2012-10-19

Authors: Viacava Follis, Ariele; ., Royappa; W., .

Citation: Follis, Ariele Viacava; ., Chipuk; C., .; ., .; ., .; 18793, .; 8, 18793; Lie, 9; White, Stephen; ., Green; W., .. "PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis."  Nat. Chem. Biol. 9, 163-168 (2013).

Assembly members:
BCL-xL_comp, polymer, 180 residues, 19845.008 Da.
PUMA_BH3, polymer, 25 residues, 3053.351 Da.

Natural source:   Common Name: not available   Taxonomy ID: 9606   Superkingdom: 2   Kingdom: $PUMA_BH3   Genus/species: not available 9606

Experimental source:   Production method: recombinant technology' 'Escherichia coli

Entity Sequences (FASTA):
BCL-xL_comp: MSAMSQSNRELVVDFLSYKL SQKGYSWSQFSDVEENRTEA PEGTESEAVKQALREAGDEF ELRYRRAFSDLTSQLHITPG TAYQSFEQVVNELFRDGVNW GRIVAFFSFGGALCVESVDK EMQVLVSRIAAWMATYLNDH LEPWIQENGGWDTFVELYGN NAAAESRKGQERLEHHHHHH
PUMA_BH3: EEQWAREIGAQLRRMADDLN AQYER

Data sets:
Data typeCount
13C chemical shifts541
1731H chemical shifts

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