BMRB Entry 17708

Name: Solution-state structures of monomeric and dimeric G-quadruplexes adopted by a sequence from N-myc
Published: 2012-03-09

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PDB ID: 2led
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17708
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution-state structures of monomeric and dimeric G-quadruplexes adopted by a sequence from N-myc

Deposition date:

2011-06-15

Original release date:

2012-03-09

Authors:

Trajkovski, Marko; Plavec, Janez; Webba da Silva, Mateus

Citation:

Citation: Trajkovski, Marko; Webba da Silva, Mateus; Plavec, Janez. "Unique Structural Features of Interconverting Monomeric and Dimeric G-Quadruplexes Adopted by a Sequence from the Intron of the N-myc Gene." J. Am. Chem. Soc. 134, 4132-4141 (2012).
PubMed: 22303871

Assembly members:

Assembly members:
N-myc, polymer, 19 residues, 6064.968 Da.

Natural source:

Natural source: Common Name: humans Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
N-myc: TAGGGCGGGAGGGAGGGAA

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
1H chemical shifts	130

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	N-myc, chain a	1
2	N-myc, chain b	1

Entities:

Entity 1, N-myc, chain a 19 residues - 6064.968 Da.

1

DT

DA

DG

DC

DG

DA

2

DG

DA

DG

DA

Samples:

sample_1: N-myc0.4 – 6.6 mM; D2O 10%; H2O 90%

sample_conditions_1: ionic strength: 120 mM; pH: 6.5; pressure: 1 atm; temperature: 298.15 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
JRHMBC	sample_1	isotropic	sample_conditions_1

Software:

AMBER v9, Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollm - structure solution

NMR spectrometers:

Varian VNMRS 800 MHz
Varian VNMRS 600 MHz