BMRB Entry 17458

Name: NMR STRUCTURE OF THYMOSIN ALPHA-1
Published: 2011-12-08

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PDB ID: 2l9i
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17458
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR STRUCTURE OF THYMOSIN ALPHA-1

Deposition date:

2011-02-11

Original release date:

2011-12-08

Authors:

Elizondo-Riojas, Miguel; Gorenstein, David; Volk, David

Citation:

Citation: Elizondo-Riojas, Miguel-Angel; Chamow, Steven; Tuthill, Cynthia; Gorenstein, David; Volk, David. "NMR structure of human thymosin alpha-1." Biochem. Biophys. Res. Commun. 416, 356-361 (2011).
PubMed: 22115779

Assembly members:

Assembly members:
Thymosin-Alpha1, polymer, 28 residues, 3070.300 Da.
ACE, non-polymer, 44.053 Da.

Natural source:

Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo Sapiens

Experimental source:

Experimental source: Production method: obtained from a vendor

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Thymosin-Alpha1: SDAAVDTSSEITTKDLKEKK EVVEEAEN

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
1H chemical shifts	188

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	Thymosin-Alpha1	1
2	ACE	2

Entities:

Entity 1, Thymosin-Alpha1 28 residues - 3070.300 Da.

1

SER

ASP

ALA

VAL

ASP

THR

SER

GLU

2

ILE

THR

LYS

ASP

LEU

LYS

GLU

LYS

3

GLU

VAL

GLU

ALA

GLU

ASN

Entity 2, ACE - C2 H4 O - 44.053 Da.

1

ACE

Samples:

sample_1: Thymosin-Alpha1 28.8 mg; TFE 40%; D2O 10%; H2O 50%

sample_conditions_1: pH: 4.9; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1

Software:

AMBER v9.0, Case, Darden, Cheatham, III, Simmerling, Wang, Duke, Luo, ... and Kollm - data analysis, minimization, molecular dynamics

NMR spectrometers:

Varian UnityPlus 800 MHz

BMRB	19901
PDB	2L9I 2MNQ
DBJ	BAC29913 BAC39141 BAC40090 BAD97325 BAE20932
EMBL	CAA39028 CAA39601 CAH92370
GB	AAA40758 AAA41931 AAA41941 AAA41942 AAA42241
PRF	770552A
REF	NP_001092755 NP_001126395 NP_001153558 NP_001291804 NP_002814
SP	P01252 P06302 P06454 P26350 Q5R790
TPG	DAA32328
AlphaFold	P01252 P06302 P06454 P26350 Q5R790