BMRB Entry 17305

Name: Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12
Published: 2011-12-02

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PDB ID: 2l6a
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17305
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Three-dimensional structure of the N-terminal effector PYRIN domain of NLRP12

Deposition date:

2010-11-17

Original release date:

2011-12-02

Authors:

Pinheiro, Anderson; Peti, Wolfgang

Citation:

Citation: Pinheiro, Anderson; Eibl, Clarissa; Ekman-Vural, Zeynep; Schwarzenbacher, Robert; Peti, Wolfgang. "Three-dimensional structure of the effector PYRIN domain of NLRP12" J. Mol. Biol. 413, 790-803 (2011).
PubMed: 21978668

Assembly members:

Assembly members:
NLRP12_PYD, polymer, 102 residues, 11722.509 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pHis parallel STOP

Entity Sequences (FASTA):

Entity Sequences (FASTA):
NLRP12_PYD: GHMLRTAGRDGLCRLSTYLE ELEAVELKKFKLYLGTATEL GEGKIPWGSMEKAGPLEMAQ LLITHFGPEEAWRLALSTFE RINRKDLWERGQREDLVRDT VE

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	402
15N chemical shifts	101
1H chemical shifts	698

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	NLRP12 PYD monomer	1

Entities:

Entity 1, NLRP12 PYD monomer 102 residues - 11722.509 Da.

Residues GLY1, HIS2, VAL101 and GLU102 were introduced by cloning and are not part of the protein sequence.

1

GLY

HIS

MET

LEU

ARG

THR

ALA

GLY

ARG

ASP

2

GLY

LEU

CYS

ARG

LEU

SER

THR

TYR

LEU

GLU

3

GLU

LEU

GLU

ALA

VAL

GLU

LEU

LYS

PHE

4

LYS

LEU

TYR

LEU

GLY

THR

ALA

THR

GLU

LEU

5

GLY

GLU

GLY

LYS

ILE

PRO

TRP

GLY

SER

MET

6

GLU

LYS

ALA

GLY

PRO

LEU

GLU

MET

ALA

GLN

7

LEU

ILE

THR

HIS

PHE

GLY

PRO

GLU

8

ALA

TRP

ARG

LEU

ALA

LEU

SER

THR

PHE

GLU

9

ARG

ILE

ASN

ARG

LYS

ASP

LEU

TRP

GLU

ARG

10

GLY

GLN

ARG

GLU

ASP

LEU

VAL

ARG

ASP

THR

11

VAL

GLU

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_2	isotropic	sample_conditions_1
3D HNCA	sample_2	isotropic	sample_conditions_1
3D HNCACB	sample_2	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_2	isotropic	sample_conditions_1
3D HNCO	sample_2	isotropic	sample_conditions_1
3D HN(CA)CO	sample_2	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_2	isotropic	sample_conditions_1
3D C(CO)NH	sample_2	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_2	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_3	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_3	isotropic	sample_conditions_1
2D 1H-1H COSY	sample_3	isotropic	sample_conditions_1

PDB	2L6A
DBJ	BAF83461 BAG53059
GB	AAH28069 AAM18227 AAM75142 AAM75143 AAM75144
REF	NP_001264055 NP_001264058 NP_653288 XP_003830191 XP_003830193
SP	P59046
AlphaFold	P59046

BMRB Entry 17305

Additional metadata:

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Entities:

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