BMRB Entry 11329

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PDB ID: 2dat
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR11329
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2

Deposition date:

2010-08-10

Original release date:

2011-08-19

Authors:

Yoneyama, M.; Kigawa, T.; Saito, K.; Tochio, N.; Koshiba, S.; Inoue, M.; Yokoyama, S.

Citation:

Citation: Yoneyama, M.; Kigawa, T.; Saito, K.; Tochio, N.; Koshiba, S.; Inoue, M.; Yokoyama, S.. "Solution structure of the Bromodomain of human SWI/SNF related matrix associated actin dependent regulator of cromatin subfamily A member 2" .

Assembly members:

Assembly members:
Bromodomain, polymer, 123 residues, Formula weight is not available

Natural source:

Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: cell free synthesis Host organism: E. coli - cell free Vector: P050302-31

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Bromodomain: GSSGSSGSPNPPKLTKQMNA IIDTVINYKDSSGRQLSEVF IQLPSRKELPEYYELIRKPV DFKKIKERIRNHKYRSLGDL EKDVMLLCHNAQTFNLEGSQ IYEDSIVLQSVFKSARQSGP SSG

Data sets:

assigned_chemical_shifts
- chemical_shift_1

Data type	Count
13C chemical shifts	528
15N chemical shifts	115
1H chemical shifts	847

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	Bromodomain	1

Entities:

Entity 1, Bromodomain 123 residues - Formula weight is not available

1

GLY

SER

GLY

SER

GLY

SER

PRO

ASN

2

PRO

LYS

LEU

THR

LYS

GLN

MET

ASN

ALA

3

ILE

ASP

THR

VAL

ILE

ASN

TYR

LYS

ASP

4

SER

GLY

ARG

GLN

LEU

SER

GLU

VAL

PHE

5

ILE

GLN

LEU

PRO

SER

ARG

LYS

GLU

LEU

PRO

6

GLU

TYR

GLU

LEU

ILE

ARG

LYS

PRO

VAL

7

ASP

PHE

LYS

ILE

LYS

GLU

ARG

ILE

ARG

8

ASN

HIS

LYS

TYR

ARG

SER

LEU

GLY

ASP

LEU

9

GLU

LYS

ASP

VAL

MET

LEU

CYS

HIS

ASN

10

ALA

GLN

THR

PHE

ASN

LEU

GLU

GLY

SER

GLN

11

ILE

TYR

GLU

ASP

SER

ILE

VAL

LEU

GLN

SER

12

VAL

PHE

LYS

SER

ALA

ARG

GLN

SER

GLY

PRO

13

SER

GLY

Samples:

sample_1: Bromodomain, [U-13C; U-15N], 1.39 mM; d-Tris-HCl 20 mM; NaCl 100 mM; d-DTT 1 mM; NaN3 0.02%; Guanidine oxalate 75 mM; H2O 90%; D2O 10%

condition_1: ionic strength: 195 mM; pH: 7.0; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
3D 15N-separated NOESY	sample_1	isotropic	condition_1
3D 13C-separated NOESY	sample_1	isotropic	condition_1

Software:

xwinnmr v3.5, Bruker - collection

NMRPipe v20030801, Delaglio, F. - processing

NMRView v5.0.4, Johnson, B. A. - data analysis

Kujira v0.9318, Kobayashi, N. - data analysis

CYANA v2.0.17, Guntert, P. - refinement, structure solution

NMR spectrometers:

Bruker AVANCE 800 MHz

PDB	2DAT
DBJ	BAA05142 BAB27925 BAC04280 BAE90149 BAG60343
EMBL	CAA62832 CAH89596
GB	AAH22975 AAH56199 AAH75641 AAI42522 AAI56186
REF	NP_001092585 NP_001124708 NP_001276326 NP_001276327 NP_001276328
SP	Q6DIC0
TPG	DAA26902
AlphaFold	Q6DIC0