BMRB Entry 11055

Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR11055

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Title:
NMR structure of Grb2 SH2 domain complexed with the inhibitor
Deposition date:
2008-08-07
Original release date:
2008-09-29
Authors:
Ogura, Kenji; Shiga, Takanori; Yokochi, Masashi; Yuzawa, Satoru; Inagaki, Fuyuhiko
Citation:

Citation: Ogura, Kenji; Shiga, Takanori; Yokochi, Masashi; Yuzawa, Satoru; Burke, Terrence; Inagaki, Fuyuhiko. "Solution structure of the Grb2 SH2 domain complexed with a high-affinity inhibitor."  J. Biomol. NMR 42, 197-207 (2008).
PubMed: 18830565

Assembly members:

Assembly members:
growth factor receptor binding protein SH2 domain, polymer, 100 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pGEX-4T

Entity Sequences (FASTA):

Entity Sequences (FASTA):
growth factor receptor binding protein SH2 domain: WFFGKIPRAKAEEMLSKQRH DGAFLIRESESAPGDFSLSV KFGNDVQHFKVLRDGAGKYF LWVVKFNSLNELVDYHRSTS VSRNQQIFLRDIEQVPQQPT

Data sets:
Data typeCount
13C chemical shifts273
15N chemical shifts103
1H chemical shifts694

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1growth factor receptor binding protein SH2 domain1

Entities:

Entity 1, growth factor receptor binding protein SH2 domain 100 residues - Formula weight is not available

1   TRPPHEPHEGLYLYSILEPROARGALALYS
2   ALAGLUGLUMETLEUSERLYSGLNARGHIS
3   ASPGLYALAPHELEUILEARGGLUSERGLU
4   SERALAPROGLYASPPHESERLEUSERVAL
5   LYSPHEGLYASNASPVALGLNHISPHELYS
6   VALLEUARGASPGLYALAGLYLYSTYRPHE
7   LEUTRPVALVALLYSPHEASNSERLEUASN
8   GLULEUVALASPTYRHISARGSERTHRSER
9   VALSERARGASNGLNGLNILEPHELEUARG
10   ASPILEGLUGLNVALPROGLNGLNPROTHR

Related Database Links:

PDB 1BM2 1BMB 1CJ1 1FHS 1FYR 1GHU 1GRI 1JYQ 1JYR 1JYU 1QG1 1TZE 1X0N 1ZFP 2AOA 2AOB 2H46 2H5K 2HUW 3C7I 3IMD 3IMJ 3IN7 3IN8 3KFJ 3MXC 3MXY 3N7Y 3N84 3N8M 3OV1 3OVE 3S8L 3S8N 3S8O 3WA4 4P9V 4P9Z
DBJ BAA08645 BAA12862 BAE28376 BAE32093 BAE33439
EMBL CAA44664 CAA44665 CAB59279 CAG29359 CAG46740
GB AAA16318 AAA58448 AAB40022 AAB49699 AAC37549
REF NP_001008130 NP_001029802 NP_001084357 NP_001085669 NP_001126954
SP P62993 P62994 P87379 Q07883 Q5R4J7
TPG DAA18091
AlphaFold P62993 P62994 P87379 Q07883 Q5R4J7

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks