BMRB Entry 5881

Title:
Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA
Deposition date:
2003-07-24
Original release date:
2003-09-16
Authors:
Keizer, David; West, Peter; Lee, Erinna; Olivera, Baldomero; Bulaj, Grzegorz; Norton, Raymond
Citation:

Citation: Keizer, David; West, Peter; Lee, Erinna; Yoshikami, Doju; Olivera, Baldomero; Bulaj, Grzegorz; Norton, Raymond. "Structural basis for tetrodotoxin-resistant sodium channel binding by mu-conotoxin SmIIIA"  J. Biol. Chem. 278, 46805-46813 (2003).
PubMed: 12970353

Assembly members:

Assembly members:
SmIIIA mu-conotoxin, polymer, 22 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Conus stercusmuscarum   Taxonomy ID: 89452   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Conus stercusmuscarum

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
SmIIIA mu-conotoxin: XRCCNGRRGCSSRWCRDHSR CC

Data sets:
Data typeCount
1H chemical shifts257

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1SmIIIA1

Entities:

Entity 1, SmIIIA 22 residues - Formula weight is not available

1   PCAARGCYSCYSASNGLYARGARGGLYCYS
2   SERSERARGTRPCYSARGASPHISSERARG
3   CYSCYS

Samples:

sample_1: SmIIIA mu-conotoxin 0.9 mM

Ex-cond_1: pH: 4.70; temperature: 278 K

Ex-cond_2: pH: 3.30; temperature: 278 K

Experiments:

NameSampleSample stateSample conditions
2D 1H-1H DQF-COSYsample_1not availablenot available
2D 1H-1H E.COSYsample_1not availablenot available
2D 1H-1H NOESYsample_1not availablenot available
2D 1H-1H TOCSYsample_1not availablenot available

Software:

No software information available

NMR spectrometers:

  • Bruker AMX 500 MHz
  • Bruker DRX 600 MHz

Related Database Links:

PDB
SWISS-PROT P60207