BMRB Entry 52729

Name: Single Alpha-Helix in the postsynaptic Drebrin protein
Published: 2025-04-08

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR52729

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Single Alpha-Helix in the postsynaptic Drebrin protein

Deposition date:

2024-11-28

Original release date:

2025-04-08

Authors:

Varga, Soma; Permi, Perttu; Gaspari, Zoltan

Citation:

Citation: Varga, Soma; Peterfia, Balint Ferenc; Dudola, Daniel; Farkas, Viktor; Jeffries, Cy; Permi, Perttu; Gaspari, Zoltan. "Dynamic Interchange of Local Residue-Residue Interactions in the Largely Extended Single Alpha-Helix in Drebrin" Biochem. J. ., .-. (2025).
PubMed: 40192062

Assembly members:

Assembly members:
entity_1, polymer, 74 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET-15b

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GSHMKDPMKRINREQFWEQA KKEEELRKEEERKKALDERL RFEQERMEQERQEQEERERR YREREQQIEEHRRK

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	281
15N chemical shifts	66
1H chemical shifts	131

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	Drebrin SAH	1

Entities:

Entity 1, Drebrin SAH 74 residues - Formula weight is not available

1

GLY

SER

HIS

MET

LYS

ASP

PRO

MET

LYS

ARG

2

ILE

ASN

ARG

GLU

GLN

PHE

TRP

GLU

GLN

ALA

3

LYS

GLU

LEU

ARG

LYS

GLU

4

GLU

ARG

LYS

ALA

LEU

ASP

GLU

ARG

LEU

5

ARG

PHE

GLU

GLN

GLU

ARG

MET

GLU

GLN

GLU

6

ARG

GLN

GLU

GLN

GLU

ARG

GLU

ARG

7

TYR

ARG

GLU

ARG

GLU

GLN

ILE

GLU

8

HIS

ARG

LYS

Samples:

sample_1: Drebrin SAH, [U-100% 13C; U-100% 15N], 0.34 mM; DSS 0.1 mM; sodium chloride 50 mM; sodium phosphate 20 mM; sodium azide 0.1 mM

sample_conditions_1: ionic strength: 0.07 M; pH: 6; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
1D 1H	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D iHNCO	sample_1	isotropic	sample_conditions_1
3D (H)CC(CO)NH	sample_1	isotropic	sample_conditions_1
3D H(CC)(CO)NH	sample_1	isotropic	sample_conditions_1
4D (HACA)N(CA)CONH	sample_1	isotropic	sample_conditions_1

Software:

TOPSPIN - collection

CcpNMR - chemical shift assignment

NMR spectrometers:

Bruker AVANCE III 800 MHz

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks