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PDB ID: 11tj
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR31296
MolProbity Validation Chart

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NMR-STAR v3 text file.
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Name: NMR solution structure of Manduca sexta moricin-6
Published: 2026-04-20

Title:

NMR solution structure of Manduca sexta moricin-6

Deposition date:

2026-03-12

Original release date:

2026-04-20

Authors:

Hou, C.; Su, A.; Combs, P.; Roy, S.; Marek, S.; Cook, G.; Prakash, O.; Jiang, H.

Citation:

Citation: Hou, C.; Su, A.; Combs, P.; Roy, S.; Marek, S.; Cook, G.; Prakash, O.; Jiang, H.. "Dipeptidyl peptidase IV processing activates Manduca sexta pro-moricin-6: structural basis of enhanced antimicrobial activity." Insect Biochem. Mol. Biol. 191, 104553-104553 (2026).
PubMed: 41941917

Assembly members:

Assembly members:
entity_1, polymer, 38 residues, 4026.761 Da.

Natural source:

Natural source: Common Name: tobacco hornworm Taxonomy ID: 7130 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Manduca sexta

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GRLSAIKKGGKIIKKGLGVI SAAGTAHEVYSHVKNRRN

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1
spectral_peak_list
- spectral_peak_list_1
- spectral_peak_list_2

Data type	Count
1H chemical shifts	259

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	unit_1	1

Entities:

Entity 1, unit_1 38 residues - 4026.761 Da.

1

GLY

ARG

LEU

SER

ALA

ILE

LYS

GLY

2

LYS

ILE

LYS

GLY

LEU

GLY

VAL

ILE

3

SER

ALA

GLY

THR

ALA

HIS

GLU

VAL

TYR

4

SER

HIS

VAL

LYS

ASN

ARG

ASN

Samples:

sample_1: moricin-6 1.2 mM

sample_conditions_1: ionic strength: 0 Not defined; pressure: 1 atm; temperature: 298 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H COSY	sample_1	isotropic	sample_conditions_1
2D DQF-COSY	sample_1	isotropic	sample_conditions_1

Software:

TopSpin, Bruker Biospin - collection

CARA, Keller and Wuthrich - chemical shift assignment

NMRPipe, Delaglio, Grzesiek, Vuister, Zhu, Pfeifer and Bax - processing

NMRFAM-SPARKY, Lee, Tonelli, and Markley - peak picking

X-PLOR NIH, Schwieters, Kuszewski, Tjandra and Clore - structure calculation

NMR spectrometers:

Bruker AVANCE 600 MHz

BMRB Entry 31296