BMRB Entry 6456

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PDB ID: 1wa7
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR6456
MolProbity Validation Chart

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Title:
NMR STRUCTURE OF THE SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE
Deposition date:
2005-01-12
Original release date:
2005-10-17
Authors:
Bauer, Finn; Schweimer, Kristian; Hoffmann, Silke; Roesch, Paul; Sticht, Heinrich
Citation:

Citation: Bauer, Finn; Schweimer, Kristian; Meiselbach, Heike; Hoffmann, Silke; Roesch, Paul; Sticht, Heinrich. "Structural characterization of Lyn-SH3 domain in complex with a herpesviral protein reveals an extended recognition motif that enhances binding affinity"  Protein Sci. 14, 2487-2498 (2005).
PubMed: 16155203

Assembly members:

Assembly members:
SH3 domain of the Lyn kinase, polymer, 68 residues, Formula weight is not available
Tyrosine kinase interacting protein, polymer, 23 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology

Entity Sequences (FASTA):

Entity Sequences (FASTA):
SH3 domain of the Lyn kinase: GPLGSPEEQGDIVVALYPYD GIHPDDLSFKKGEKMKVLEE HGEWWKAKSLLTKKEGFIPS NYVAKLNT
Tyrosine kinase interacting protein: TWDPGMPTPPLPPRPANLGE RQA

Data sets:
Data typeCount
1H chemical shifts642
13C chemical shifts321
15N chemical shifts84

Additional metadata:

  • Assembly
  • Samples and Experiments
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  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1LynSH3 monomer1
2TIP monomer2

Entities:

Entity 1, LynSH3 monomer 68 residues - Formula weight is not available

1   GLYPROLEUGLYSERPROGLUGLUGLNGLY
2   ASPILEVALVALALALEUTYRPROTYRASP
3   GLYILEHISPROASPASPLEUSERPHELYS
4   LYSGLYGLULYSMETLYSVALLEUGLUGLU
5   HISGLYGLUTRPTRPLYSALALYSSERLEU
6   LEUTHRLYSLYSGLUGLYPHEILEPROSER
7   ASNTYRVALALALYSLEUASNTHR

Entity 2, TIP monomer 23 residues - Formula weight is not available

1   THRTRPASPPROGLYMETPROTHRPROPRO
2   LEUPROPROARGPROALAASNLEUGLYGLU
3   ARGGLNALA

Related Database Links:

PDB 1WA7
EMBL CAC84294 CAC84987 CAC84987 CAC84294
GB AAA72928
PIR A34770 A34770
SP P22575
SWISS-PROT P22575
GenBank AAA72928
AlphaFold P22575

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks