BMRB Entry 5583

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PDB ID: 1l3h
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR5583
MolProbity Validation Chart

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Title:
NMR structure of P41icf, a potent inhibitor of human cathepsin L
Deposition date:
2002-11-06
Original release date:
2003-05-14
Authors:
Chiva, C.; Barthe, P.; Codina, A.; Giralt, E.
Citation:

Citation: Chiva, C.; Barthe, P.; Codina, A.; Gairi, M.; Molina, F.; Granier, C.; Pugniere, M.; Inui, T.; Nishio, H.; Nishiuchi, Y.; Kimura, T.; Sakakibara, S.; Albericio, F.; Giralt, E.. "Synthesis and NMR Structure of P41icf, a Potent Inhibitor of Human Cathepsin L"  J. Am. Chem. Soc. 125, 1508-1517 (2003).
PubMed: 12568610

Assembly members:

Assembly members:
MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf), polymer, 65 residues, 7246 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT (P41icf): LTKCQEEVSHIPAVHPGSFR PKCDENGNYLPLQCYGSIGY CWCVFPNGTEVPNTRSRGHH NCSES

Data sets:
Data typeCount
1H chemical shifts383
coupling constants42

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT1

Entities:

Entity 1, MHC CLASS II-ASSOCIATED P41 INVARIANT CHAIN FRAGMENT 65 residues - 7246 Da.

1   LEUTHRLYSCYSGLNGLUGLUVALSERHIS
2   ILEPROALAVALHISPROGLYSERPHEARG
3   PROLYSCYSASPGLUASNGLYASNTYRLEU
4   PROLEUGLNCYSTYRGLYSERILEGLYTYR
5   CYSTRPCYSVALPHEPROASNGLYTHRGLU
6   VALPROASNTHRARGSERARGGLYHISHIS
7   ASNCYSSERGLUSER

Related Database Links:

PDB 1ICF 1L3H
DBJ BAG60210
GB AAA35996 EAW61731
REF NP_001020330 XP_003266686 XP_003829068 XP_004042860 XP_008986092
SP P04233
AlphaFold P04233