BMRB Entry 4379

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR4379

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR Solution Structure of the Human Prion Protein Domain reveals Species Dependent Structural Disorder and Intramolecular Association with the Flexible Tail

Deposition date:

1999-08-18

Original release date:

2000-02-01

Authors:

Zahn, Ralph; Aizhuo, Liu; Luhrs, Thorsten; Wuthrich, Kurt

Citation:

Citation: Zahn, Ralph; Liu, Aizhuo; Luhrs, Thorsten; Riek, Roland; von Schroetter, Christine; Lopez Garcia, Francisco; Billeter, Martin; Calzolai, Luigi; Wider, Gerhard; Wuthrich, Kurt. "NMR Solution Structure of the Human Prion Protein" Proc. Natl. Acad. Sci. U. S. A. 97, 145-150 (2000).

Assembly members:

Assembly members:
human prion protein, polymer, 112 residues, 13246 Da.

Natural source:

Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology

Entity Sequences (FASTA):

Entity Sequences (FASTA):
human prion protein: GSVVGGLGGYMLGSAMSRPI IHFGSDYEDRYYRENMHRYP NQVYYRPMDEYSNQNNFVHD CVNITIKQHTVTTTTKGENF TETDVKMMERVVEQMCITQY ERESQAYYQRGS

Data sets:

assigned_chemical_shifts
- CSS

Data type	Count
13C chemical shifts	354
15N chemical shifts	126
1H chemical shifts	767

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	hPrP(121-230)	1

Entities:

Entity 1, hPrP(121-230) 112 residues - 13246 Da.

1

GLY

SER

VAL

GLY

LEU

GLY

TYR

2

MET

LEU

GLY

SER

ALA

MET

SER

ARG

PRO

ILE

3

ILE

HIS

PHE

GLY

SER

ASP

TYR

GLU

ASP

ARG

4

TYR

ARG

GLU

ASN

MET

HIS

ARG

TYR

PRO

5

ASN

GLN

VAL

TYR

ARG

PRO

MET

ASP

GLU

6

TYR

SER

ASN

GLN

ASN

PHE

VAL

HIS

ASP

7

CYS

VAL

ASN

ILE

THR

ILE

LYS

GLN

HIS

THR

8

VAL

THR

LYS

GLY

GLU

ASN

PHE

9

THR

GLU

THR

ASP

VAL

LYS

MET

GLU

ARG

10

VAL

GLU

GLN

MET

CYS

ILE

THR

GLN

TYR

11

GLU

ARG

GLU

SER

GLN

ALA

TYR

GLN

ARG

12

GLY

SER

Samples:

sample_1: human prion protein 1.0 mM

sample_2: human prion protein, [U-15N], 1.0 mM

sample_3: human prion protein, [U-15N; U-13C], 1.0 mM

Ex-cond_1: ionic strength: 0.01 M; pH: 4.5; temperature: 293 K

Experiments:

Name	Sample	Sample state	Sample conditions
1H-1H-15N NOESY	not available	not available	not available
1H-1H-13C NOESY	not available	not available	not available
HCCH COSY	not available	not available	not available
HCCH TOCSY	not available	not available	not available
HNCA	not available	not available	not available
HNCACB	not available	not available	not available

Software:

PROSA -

XEASY -

DYANA -

NMR spectrometers:

Bruker DRX 600 MHz
Bruker DRX 750 MHz

BMRB	15676 16743 17714 17756 17757 17780 18426 18550 19268 4402 4434 4620 4641 4736
PDB	1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2K1D 2KUN 2LEJ 2LFT 2LSB 2LV1 2M8T 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 4DGI 4KML 4N9O
DBJ	BAA00011 BAF62360 BAG32276 BAG32277 BAG32278
EMBL	CAA58442 CAG46836 CAG46869
GB	AAA19664 AAA60182 AAA68632 AAA68633 AAB59442
REF	NP_000302 NP_001009093 NP_001073590 NP_001073591 NP_001073592
SP	P04156 P40252 P61766 P61767 P61768
AlphaFold	P04156 P40252 P61766 P61767 P61768