BMRB Entry 34095

Name: Structure Of P63 SAM Domain L514F Mutant Causative Of AEC Syndrome
Published: 2018-02-02

Click here to enlarge.

PDB ID: 5n2o
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR34095
MolProbity Validation Chart

NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry

Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

Select model:

I am color blind

Download raw data. Direct link to this display. Help

Title:

Structure Of P63 SAM Domain L514F Mutant Causative Of AEC Syndrome

Deposition date:

2017-02-08

Original release date:

2018-02-02

Authors:

Rinnenthal, J.; Wuerz, J.; Osterburg, C.; Guentert, P.; Doetsch, V.

Citation:

Citation: Russo, Claudia; Osterburg, Christian; Sirico, Anna; Antonini, Dario; Ambrosio, Raffaele; Wurz, Julia Maren; Rinnenthal, Jorg; Ferniani, Marco; Kehrloesser, Sebastian; Schafer, Birgit; Guntert, Peter; Sinha, Satrajit; Dotsch, Volker; Missero, Caterina. "Protein aggregation of the p63 transcription factor underlies severe skin fragility in AEC syndrome" Proc. Natl. Acad. Sci. U. S. A. 115, E906-E915 (2018).
PubMed: 29339502

Assembly members:

Assembly members:
entity_1, polymer, 70 residues, 7957.985 Da.

Natural source:

Natural source: Common Name: House Mouse Taxonomy ID: 10090 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Mus musculus

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GPLGSTDCSIVSFFARLGCS SCLDYFTTQGLTTIYQIEHY SMDDLASLKIPEQFRHAIWK GILDHRQLHD

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	113
15N chemical shifts	61
1H chemical shifts	413

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
Hide all

Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	entity_1	1

Entities:

Entity 1, entity_1 70 residues - 7957.985 Da.

1	GLY	PRO	LEU	GLY	SER	THR	ASP	CYS	SER	ILE
2	VAL	SER	PHE	PHE	ALA	ARG	LEU	GLY	CYS	SER
3	SER	CYS	LEU	ASP	TYR	PHE	THR	THR	GLN	GLY
4	LEU	THR	THR	ILE	TYR	GLN	ILE	GLU	HIS	TYR
5	SER	MET	ASP	ASP	LEU	ALA	SER	LEU	LYS	ILE
6	PRO	GLU	GLN	PHE	ARG	HIS	ALA	ILE	TRP	LYS
7	GLY	ILE	LEU	ASP	HIS	ARG	GLN	LEU	HIS	ASP

Name	Sample	Sample state	Sample conditions
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D 1H-15N TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_2	isotropic	sample_conditions_1

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks

BMRB Entry 34095

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

1	GLY	PRO	LEU	GLY	SER	THR	ASP	CYS	SER	ILE
2	VAL	SER	PHE	PHE	ALA	ARG	LEU	GLY	CYS	SER
3	SER	CYS	LEU	ASP	TYR	PHE	THR	THR	GLN	GLY
4	LEU	THR	THR	ILE	TYR	GLN	ILE	GLU	HIS	TYR
5	SER	MET	ASP	ASP	LEU	ALA	SER	LEU	LYS	ILE
6	PRO	GLU	GLN	PHE	ARG	HIS	ALA	ILE	TRP	LYS
7	GLY	ILE	LEU	ASP	HIS	ARG	GLN	LEU	HIS	ASP

1	GLY	PRO	LEU	GLY	SER	THR	ASP	CYS	SER	ILE
2	VAL	SER	PHE	PHE	ALA	ARG	LEU	GLY	CYS	SER
3	SER	CYS	LEU	ASP	TYR	PHE	THR	THR	GLN	GLY
4	LEU	THR	THR	ILE	TYR	GLN	ILE	GLU	HIS	TYR
5	SER	MET	ASP	ASP	LEU	ALA	SER	LEU	LYS	ILE
6	PRO	GLU	GLN	PHE	ARG	HIS	ALA	ILE	TRP	LYS
7	GLY	ILE	LEU	ASP	HIS	ARG	GLN	LEU	HIS	ASP

1	GLY	PRO	LEU	GLY	SER	THR	ASP	CYS	SER	ILE
2	VAL	SER	PHE	PHE	ALA	ARG	LEU	GLY	CYS	SER
3	SER	CYS	LEU	ASP	TYR	PHE	THR	THR	GLN	GLY
4	LEU	THR	THR	ILE	TYR	GLN	ILE	GLU	HIS	TYR
5	SER	MET	ASP	ASP	LEU	ALA	SER	LEU	LYS	ILE
6	PRO	GLU	GLN	PHE	ARG	HIS	ALA	ILE	TRP	LYS
7	GLY	ILE	LEU	ASP	HIS	ARG	GLN	LEU	HIS	ASP