BMRB Entry 34079

Name: Solution NMR structure of hnRNP A1 RRM1 in complex with 5&#039;-UUAGGUC-3&#039; RNA
Published: 2017-11-29

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PDB ID: 5mpg
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR34079
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution NMR structure of hnRNP A1 RRM1 in complex with 5'-UUAGGUC-3' RNA

Deposition date:

2016-12-16

Original release date:

2017-11-29

Authors:

Barraud, P.; Allain, F.

Citation:

Citation: Beusch, Irene; Barraud, Pierre; Moursy, Ahmed; Clery, Antoine; Allain, Frederic Hai-Trieu. "Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7" Elife 6, e25736-e25736 (2017).
PubMed: 28650318

Assembly members:

Assembly members:
entity_1, polymer, 97 residues, 11003.271 Da.
entity_2, polymer, 7 residues, 2198.339 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: ASKSESPKEPEQLRKLFIGG LSFETTDESLRSHFEQWGTL TDCVVMRDPNTKRSRGFGFV TYATVEEVDAAMNARPHKVD GRVVEPKRAVSREDSQR
entity_2: UUAGGUC

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	293
15N chemical shifts	93
1H chemical shifts	637

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	entity_1	1
2	entity_2	2

Entities:

Entity 1, entity_1 97 residues - 11003.271 Da.

1

ALA

SER

LYS

SER

GLU

SER

PRO

LYS

GLU

PRO

2

GLU

GLN

LEU

ARG

LYS

LEU

PHE

ILE

GLY

3

LEU

SER

PHE

GLU

THR

ASP

GLU

SER

LEU

4

ARG

SER

HIS

PHE

GLU

GLN

TRP

GLY

THR

LEU

5

THR

ASP

CYS

VAL

MET

ARG

ASP

PRO

ASN

6

THR

LYS

ARG

SER

ARG

GLY

PHE

GLY

PHE

VAL

7

THR

TYR

ALA

THR

VAL

GLU

VAL

ASP

ALA

8

ALA

MET

ASN

ALA

ARG

PRO

HIS

LYS

VAL

ASP

9

GLY

ARG

VAL

GLU

PRO

LYS

ARG

ALA

VAL

10

SER

ARG

GLU

ASP

SER

GLN

ARG

Entity 2, entity_2 7 residues - 2198.339 Da.

1

U

A

G

U

C

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	not available	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_4	not available	sample_conditions_1
2D 1H-13C HSQC aromatic	sample_4	not available	sample_conditions_1
3D HNCA	sample_2	not available	sample_conditions_1
3D HNCACB	sample_2	not available	sample_conditions_1
3D CBCA(CO)NH	sample_2	not available	sample_conditions_1
3D HNCO	sample_2	not available	sample_conditions_1
3D HCc(CO)NH TOCSY	sample_2	not available	sample_conditions_1
3D hCC(CO)NH TOCSY	sample_2	not available	sample_conditions_1
3D 1H-15N NOESY	sample_1	not available	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_2	not available	sample_conditions_1
3D F1eF3f 13C-filtered/edited NOESY	sample_4	not available	sample_conditions_1
2D F1fF2f 13C-filtered NOESY	sample_4	not available	sample_conditions_1
2D 1H-1H TOCSY	sample_3	not available	sample_conditions_1
2D 1H-1H NOESY	sample_3	not available	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_2	not available	sample_conditions_1

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks

BMRB Entry 34079

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers: