BMRB Entry 27602
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR27602
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Citation: Lecoq, Lauriane; Wiegand, Thomas; Rodriguez-Alvarez, Francisco; Cadalbert, Riccardo; Herrera, Guillermo; Del Pozo-Yauner, Luis; Meier, Beat; Bockmann, Anja. "A Substantial Structural Conversion of the Native Monomer Leads to In-Register Parallel Amyloid Fibril Formation in Light Chain Amyloidosis" Chembiochem 20, 1027-1031 (2019).
PubMed: 30565364
Assembly members:
6aJL2, polymer, 111 residues, 11853.8 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET27b
Entity Sequences (FASTA):
6aJL2: NFMLTQPHSVSESPGKTVTI
SCTGSSGSIASNYVQWYQQR
PGSSPTTVIYEDNQRPSGVP
DRFSGSIDSSSNSASLTISG
LKTEDEADYYCQSYDSSNHV
VFGGGTKLTVL
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 557 |
| 15N chemical shifts | 158 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | 6aJL2 | 1 |
Entities:
Entity 1, 6aJL2 111 residues - 11853.8 Da.
R24G mutation (increased fibrillogenicity)
| 1 | ASN | PHE | MET | LEU | THR | GLN | PRO | HIS | SER | VAL | ||||
| 2 | SER | GLU | SER | PRO | GLY | LYS | THR | VAL | THR | ILE | ||||
| 3 | SER | CYS | THR | GLY | SER | SER | GLY | SER | ILE | ALA | ||||
| 4 | SER | ASN | TYR | VAL | GLN | TRP | TYR | GLN | GLN | ARG | ||||
| 5 | PRO | GLY | SER | SER | PRO | THR | THR | VAL | ILE | TYR | ||||
| 6 | GLU | ASP | ASN | GLN | ARG | PRO | SER | GLY | VAL | PRO | ||||
| 7 | ASP | ARG | PHE | SER | GLY | SER | ILE | ASP | SER | SER | ||||
| 8 | SER | ASN | SER | ALA | SER | LEU | THR | ILE | SER | GLY | ||||
| 9 | LEU | LYS | THR | GLU | ASP | GLU | ALA | ASP | TYR | TYR | ||||
| 10 | CYS | GLN | SER | TYR | ASP | SER | SER | ASN | HIS | VAL | ||||
| 11 | VAL | PHE | GLY | GLY | GLY | THR | LYS | LEU | THR | VAL | ||||
| 12 | LEU |