BMRB Entry 27287

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR27287

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Title:
Catalytic Domain of Human Aprataxin
Deposition date:
2017-10-18
Original release date:
2018-07-17
Authors:
Mueller, Geoffrey; Tumbale, Percy; Schellenberg, Matthew; Williams, Scott; London, Robert
Citation:

Citation: Tumbale, Percy; Schellenberg, Matthew; Mueller, Geoffrey; Fairweather, Emma; Watson, Mandy; Little, Jessica; Krahn, Juno; Waddell, Ian; London, Robert; Williams, R Scott. "Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease"  EMBO J. 37, e98875-e98875 (2018).
PubMed: 29934293

Assembly members:

Assembly members:
hAPTX, polymer, 192 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET

Entity Sequences (FASTA):

Entity Sequences (FASTA):
hAPTX: GSHMKDAPIKKESLGHWSQG LKISMQDPKMQVYKDEQVVV IKDKYPKARYHWLVLPWTSI SSLKAVAREHLELLKHMHTV GEKVIVDFAGSSKLRFRLGY HAIPSMSHVHLHVISQDFDS PCLKNKKHWNSFNTEYFLES QAVIEMVQEAGRVTVRDGMP ELLKLPLRCHECQQLLPSIP QLKEHLRKHWTQ

Data sets:
Data typeCount
13C chemical shifts312
15N chemical shifts149
1H chemical shifts149

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1APTX1

Entities:

Entity 1, APTX 192 residues - Formula weight is not available

1   GLYSERHISMETLYSASPALAPROILELYS
2   LYSGLUSERLEUGLYHISTRPSERGLNGLY
3   LEULYSILESERMETGLNASPPROLYSMET
4   GLNVALTYRLYSASPGLUGLNVALVALVAL
5   ILELYSASPLYSTYRPROLYSALAARGTYR
6   HISTRPLEUVALLEUPROTRPTHRSERILE
7   SERSERLEULYSALAVALALAARGGLUHIS
8   LEUGLULEULEULYSHISMETHISTHRVAL
9   GLYGLULYSVALILEVALASPPHEALAGLY
10   SERSERLYSLEUARGPHEARGLEUGLYTYR
11   HISALAILEPROSERMETSERHISVALHIS
12   LEUHISVALILESERGLNASPPHEASPSER
13   PROCYSLEULYSASNLYSLYSHISTRPASN
14   SERPHEASNTHRGLUTYRPHELEUGLUSER
15   GLNALAVALILEGLUMETVALGLNGLUALA
16   GLYARGVALTHRVALARGASPGLYMETPRO
17   GLULEULEULYSLEUPROLEUARGCYSHIS
18   GLUCYSGLNGLNLEULEUPROSERILEPRO
19   GLNLEULYSGLUHISLEUARGLYSHISTRP
20   THRGLN

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