BMRB Entry 26867

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PDB ID: 5u4k
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR26867
MolProbity Validation Chart

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Title:
HADDOCK model of the complex between the KIX domain of CBP and the transactivation domain of p65
Deposition date:
2016-08-04
Original release date:
2017-03-02
Authors:
Lecoq, Lauriane; Raiola, L.; Cyr, N.; Chabot, P.; Arseneault, G.; Omichinski, J.
Citation:

Citation: Lecoq, Lauriane; Raiola, Luca; Chabot, Philippe; Cyr, Normand; Arseneault, Genevieve; Legault, Pascale; Omichinski, James. "Structural characterization of interactions between transactivation domain 1 of the p65 subunit of NF-kB and transcription regulatory factors"  Nucleic Acids Res. 45, 5564-5576 (2017).
PubMed: 28334776

Assembly members:

Assembly members:
CREB-BINDING_PROTEIN, polymer, 87 residues, 10339.847 Da.
TRANSCRIPTION_FACTOR_P65, polymer, 33 residues, 3373.5739 Da.

Natural source:

Natural source:   Common Name: Mouse   Taxonomy ID: 10090   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Mus musculus

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET21a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
CREB-BINDING_PROTEIN: GVRKGWHEHVTQDLRSHLVH KLVQAIFPTPDPAALKDRRM ENLVAYAKKVEGDMYESANS RDEYYHLLAEKIYKIQKELE EKRRSRL
TRANSCRIPTION_FACTOR_P65: GSPGYPNGLLSGDEDFSSIA DMDFSALLSQISS

Data sets:
Data typeCount
13C chemical shifts476
15N chemical shifts118
1H chemical shifts636

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1CREB-BINDING PROTEIN1
2TRANSCRIPTION FACTOR P652

Entities:

Entity 1, CREB-BINDING PROTEIN 87 residues - 10339.847 Da.

1   GLYVALARGLYSGLYTRPHISGLUHISVAL
2   THRGLNASPLEUARGSERHISLEUVALHIS
3   LYSLEUVALGLNALAILEPHEPROTHRPRO
4   ASPPROALAALALEULYSASPARGARGMET
5   GLUASNLEUVALALATYRALALYSLYSVAL
6   GLUGLYASPMETTYRGLUSERALAASNSER
7   ARGASPGLUTYRTYRHISLEULEUALAGLU
8   LYSILETYRLYSILEGLNLYSGLULEUGLU
9   GLULYSARGARGSERARGLEU

Entity 2, TRANSCRIPTION FACTOR P65 33 residues - 3373.5739 Da.

1   GLYSERPROGLYTYRPROASNGLYLEULEU
2   SERGLYASPGLUASPPHESERSERILEALA
3   ASPMETASPPHESERALALEULEUSERGLN
4   ILESERSER

Related Database Links:

UNP CBP_MOUSE TF65_HUMAN
AlphaFold E9QPH4 Q6SLK1

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks