BMRB Entry 26780

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PDB ID: 6hpi
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR26780
MolProbity Validation Chart

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Title:
Chemical Shift Assignments for Interleukin-36alpha
Deposition date:
2016-04-18
Original release date:
2017-04-25
Authors:
Ohlenschlaeger, Oliver; Goradia, Nishit
Citation:

Citation: Goradia, Nishit; Wissbrock, Amelie; Wiedemann, Christoph; Bordusa, Frank; Ramachandran, Ramadurai; Imhof, Diana; Ohlenschlaeger, Oliver. "(1)H, (13)C, and (15)N resonance assignments for the pro-inflammatory cytokine interleukin-36alpha"  Biomol. NMR Assign. 10, 329-333 (2016).
PubMed: 27351892

Assembly members:

Assembly members:
Interleukin-36alpha, polymer, 161 residues, 17965.6 Da.

Natural source:

Natural source:   Common Name: humans   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET-28a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Interleukin-36alpha: GSHMEKALKIDTPQQGSIQD INHRVWVLQDQTLIAVPRKD RMSPVTIALISCRHVETLEK DRGNPIYLGLNGLNLCLMCA KVGDQPTLQLKEKDIMDLYN QPEPVKSFLFYHSQSGRNST FESVAFPGWFIAVSSEGGCP LILTQELGKANTTDFGLTML F

Data sets:
Data typeCount
13C chemical shifts645
15N chemical shifts144
1H chemical shifts1030

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1IL36A1

Entities:

Entity 1, IL36A 161 residues - 17965.6 Da.

Residues 1-3 represent a non-native cloning artifact

1   GLYSERHISMETGLULYSALALEULYSILE
2   ASPTHRPROGLNGLNGLYSERILEGLNASP
3   ILEASNHISARGVALTRPVALLEUGLNASP
4   GLNTHRLEUILEALAVALPROARGLYSASP
5   ARGMETSERPROVALTHRILEALALEUILE
6   SERCYSARGHISVALGLUTHRLEUGLULYS
7   ASPARGGLYASNPROILETYRLEUGLYLEU
8   ASNGLYLEUASNLEUCYSLEUMETCYSALA
9   LYSVALGLYASPGLNPROTHRLEUGLNLEU
10   LYSGLULYSASPILEMETASPLEUTYRASN
11   GLNPROGLUPROVALLYSSERPHELEUPHE
12   TYRHISSERGLNSERGLYARGASNSERTHR
13   PHEGLUSERVALALAPHEPROGLYTRPPHE
14   ILEALAVALSERSERGLUGLYGLYCYSPRO
15   LEUILELEUTHRGLNGLULEUGLYLYSALA
16   ASNTHRTHRASPPHEGLYLEUTHRMETLEU
17   PHE

Related Database Links:

UNP Q9UHA7
AlphaFold Q7RTZ8

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