BMRB Entry 26648

Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR26648

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Title:
FVO Plasmodium falciparum AMA1
Deposition date:
2015-09-04
Original release date:
2018-06-27
Authors:
Krishnarjuna, Bankala; Lim, San Sui; Devine, Shane; Debono, Cael; Lam, Raymond; Chandrashekaran, Indu; Jaipuria, Garima; Yagi, Hiromasa; MacRaild, Christopher; Atreya, Hanudatta; Anders, Robin; Scanlon, Martin; Scammells, Peter; Norton, Raymond
Citation:

Citation: Krishnarjuna, Bankala; Lim, San Sui; Devine, Shane; Debono, Cael; Lam, Raymond; Chandrashekaran, Indu; Jaipuria, Garima; Yagi, Hiromasa; Atreya, Hanudatta; Scanlon, Martin; MacRaild, Christopher; Scammells, Peter; Norton, Raymond. "Solution NMR characterization of apical membrane antigen 1 and small molecule interactions as a basis for designing new antimalarials"  J. Mol. Recognit. 29, 281-291 (2016).
PubMed: 26804042

Assembly members:

Assembly members:
FVO_PfAMA1, polymer, 335 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: malaria parasite P. falciparum   Taxonomy ID: 5833   Superkingdom: Eukaryota   Kingdom: not available   Genus/species: Plasmodium falciparum

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pPROEX HTb

Entity Sequences (FASTA):

Entity Sequences (FASTA):
FVO_PfAMA1: NYMGNPWTEYMAKYDIEEVH GSGIRVDLGEDAEVAGTQYR LPSGKCPVFGKGIIIENSNT TFLKPVATGNQDLKDGGFAF PPTNPLISPMTLNGMRDFYK NNEYVKNLDELTLCSRHAGN MNPDNDKNSNYKYPAVYDYN DKKCHILYIAAFRNNGPRYC NKDQSKRNSMFCFKPAKDKL FENYTYLSKNVVDNWEEVCP RKNLENAKFGLWVDGNCEDI PHVNEFSANNDFLCNKLVFE LSASDQPKQYEQHLTDYEKI KEGFKNKNASMIKSAFLPTG AFKADRYKSHGKGYNWGNYN RETQKCEIFNVKPTCLINNS SYIATTALSHPIEVE

Data sets:
Data typeCount
13C chemical shifts403
15N chemical shifts218
1H chemical shifts218

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1Hydrophobic cleft1

Entities:

Entity 1, Hydrophobic cleft 335 residues - Formula weight is not available

1   ASNTYRMETGLYASNPROTRPTHRGLUTYR
2   METALALYSTYRASPILEGLUGLUVALHIS
3   GLYSERGLYILEARGVALASPLEUGLYGLU
4   ASPALAGLUVALALAGLYTHRGLNTYRARG
5   LEUPROSERGLYLYSCYSPROVALPHEGLY
6   LYSGLYILEILEILEGLUASNSERASNTHR
7   THRPHELEULYSPROVALALATHRGLYASN
8   GLNASPLEULYSASPGLYGLYPHEALAPHE
9   PROPROTHRASNPROLEUILESERPROMET
10   THRLEUASNGLYMETARGASPPHETYRLYS
11   ASNASNGLUTYRVALLYSASNLEUASPGLU
12   LEUTHRLEUCYSSERARGHISALAGLYASN
13   METASNPROASPASNASPLYSASNSERASN
14   TYRLYSTYRPROALAVALTYRASPTYRASN
15   ASPLYSLYSCYSHISILELEUTYRILEALA
16   ALAPHEARGASNASNGLYPROARGTYRCYS
17   ASNLYSASPGLNSERLYSARGASNSERMET
18   PHECYSPHELYSPROALALYSASPLYSLEU
19   PHEGLUASNTYRTHRTYRLEUSERLYSASN
20   VALVALASPASNTRPGLUGLUVALCYSPRO
21   ARGLYSASNLEUGLUASNALALYSPHEGLY
22   LEUTRPVALASPGLYASNCYSGLUASPILE
23   PROHISVALASNGLUPHESERALAASNASN
24   ASPLEUGLUCYSASNLYSLEUVALPHEGLU
25   LEUSERALASERASPGLNPROLYSGLNTYR
26   GLUGLNHISLEUTHRASPTYRGLULYSILE
27   LYSGLUGLYPHELYSASNLYSASNALASER
28   METILELYSSERALAPHELEUPROTHRGLY
29   ALAPHELYSALAASPARGTYRLYSSERHIS
30   GLYLYSGLYTYRASNTRPGLYASNTYRASN
31   ARGGLUTHRGLNLYSCYSGLUILEPHEASN
32   VALLYSPROTHRCYSLEUILEASNASNSER
33   SERTYRILEALATHRTHRALALEUSERHIS
34   PROILEGLUVALGLU

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