BMRB Entry 25986

Name: Solution structure of the F87M/L110M variant of transthyretin in the monomeric state
Published: 2017-02-16

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PDB ID: 2nbo
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR25986
MolProbity Validation Chart

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of the F87M/L110M variant of transthyretin in the monomeric state

Deposition date:

2016-03-09

Original release date:

2017-02-16

Authors:

Kim, Jin Hae; Oroz, Javier; Zweckstetter, Markus

Citation:

Citation: Oroz, Javier; Kim, Jin Hae; Chang, Bliss; Zweckstetter, Markus. "Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90" Nat. Struct. Mol. Biol. 24, 407-413 (2017).
PubMed: 28218749

Assembly members:

Assembly members:
M-TTR, polymer, 127 residues, 13779.540 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pQE

Entity Sequences (FASTA):

Entity Sequences (FASTA):
M-TTR: GPTGTGESKCPLMVKVLDAV RGSPAINVAVHVFRKAADDT WEPFASGKTSESGELHGLTT EEEFVEGIYKVEIDTKSYWK ALGISPMHEHAEVVFTANDS GPRRYTIAAMLSPYSYSTTA VVTNPKE

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	308
15N chemical shifts	102
1H chemical shifts	706

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	transthyretin	1

Entities:

Entity 1, transthyretin 127 residues - 13779.540 Da.

1

GLY

PRO

THR

GLY

THR

GLY

GLU

SER

LYS

CYS

2

PRO

LEU

MET

VAL

LYS

VAL

LEU

ASP

ALA

VAL

3

ARG

GLY

SER

PRO

ALA

ILE

ASN

VAL

ALA

VAL

4

HIS

VAL

PHE

ARG

LYS

ALA

ASP

THR

5

TRP

GLU

PRO

PHE

ALA

SER

GLY

LYS

THR

SER

6

GLU

SER

GLY

GLU

LEU

HIS

GLY

LEU

THR

7

GLU

PHE

VAL

GLU

GLY

ILE

TYR

LYS

8

VAL

GLU

ILE

ASP

THR

LYS

SER

TYR

TRP

LYS

9

ALA

LEU

GLY

ILE

SER

PRO

MET

HIS

GLU

HIS

10

ALA

GLU

VAL

PHE

THR

ALA

ASN

ASP

SER

11

GLY

PRO

ARG

TYR

THR

ILE

ALA

MET

12

LEU

SER

PRO

TYR

SER

TYR

SER

THR

ALA

13

VAL

THR

ASN

PRO

LYS

GLU

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_D2O	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_D2O	isotropic	sample_conditions_1

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CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks

BMRB Entry 25986

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers: