BMRB Entry 25805
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PDB ID: 2n7g
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR25805
MolProbity Validation Chart
NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry
Citation: Li, Yan; Ng, Hui Qi; Li, Qingxin; Kang, CongBao. "Structure of the Cyclic Nucleotide-Binding Homology Domain of the hERG Channel and Its Insight into Type 2 Long QT Syndrom" Sci. Rep. 6, 23712-23712 (2016).
PubMed: 27025590
Assembly members:
the_cyclic_nucleotide-binding_homology_domain_of_the_hERG_channel, polymer, 154 residues, 14750.103 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: PNIC28-Bsa4
Entity Sequences (FASTA):
the_cyclic_nucleotide-binding_homology_domain_of_the_hERG_channel: MHHHHHHSSGVDLGTENLYF
QSMRSLLQHCKPFRGATKGC
LRALAMKFKTTHAPPGDTLV
HAGDLLTALYFISRGSIEIL
RGDVVVAILGKNDIFGEPLN
LYARPGKSNGDVRALTYCDL
HKIHRDDLLEVLDMYPEFSD
HFWSSLEITFNLRD
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 508 |
| 15N chemical shifts | 125 |
| 1H chemical shifts | 845 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | cyclic nucleotide-binding homology domain of hERG channel | 1 |
Entities:
Entity 1, cyclic nucleotide-binding homology domain of hERG channel 154 residues - 14750.103 Da.
| 1 | MET | HIS | HIS | HIS | HIS | HIS | HIS | SER | SER | GLY | ||||
| 2 | VAL | ASP | LEU | GLY | THR | GLU | ASN | LEU | TYR | PHE | ||||
| 3 | GLN | SER | MET | ARG | SER | LEU | LEU | GLN | HIS | CYS | ||||
| 4 | LYS | PRO | PHE | ARG | GLY | ALA | THR | LYS | GLY | CYS | ||||
| 5 | LEU | ARG | ALA | LEU | ALA | MET | LYS | PHE | LYS | THR | ||||
| 6 | THR | HIS | ALA | PRO | PRO | GLY | ASP | THR | LEU | VAL | ||||
| 7 | HIS | ALA | GLY | ASP | LEU | LEU | THR | ALA | LEU | TYR | ||||
| 8 | PHE | ILE | SER | ARG | GLY | SER | ILE | GLU | ILE | LEU | ||||
| 9 | ARG | GLY | ASP | VAL | VAL | VAL | ALA | ILE | LEU | GLY | ||||
| 10 | LYS | ASN | ASP | ILE | PHE | GLY | GLU | PRO | LEU | ASN | ||||
| 11 | LEU | TYR | ALA | ARG | PRO | GLY | LYS | SER | ASN | GLY | ||||
| 12 | ASP | VAL | ARG | ALA | LEU | THR | TYR | CYS | ASP | LEU | ||||
| 13 | HIS | LYS | ILE | HIS | ARG | ASP | ASP | LEU | LEU | GLU | ||||
| 14 | VAL | LEU | ASP | MET | TYR | PRO | GLU | PHE | SER | ASP | ||||
| 15 | HIS | PHE | TRP | SER | SER | LEU | GLU | ILE | THR | PHE | ||||
| 16 | ASN | LEU | ARG | ASP |
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CSV: Backbone
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SPARKY: Backbone
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