BMRB Entry 25698

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR25698

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Title:
human CFTR NBD1 deltaRI F508del mutant chemical shift assignments
Deposition date:
2015-07-09
Original release date:
2015-08-12
Authors:
Hudson, Rhea; Chong, Andrew; Forman-Kay, Julie
Citation:

Citation: Chong, Andrew; Farber, Patrick; Vernon, Robert; Hudson, Rhea; Mittermaier, Anthony; Forman-Kay, Julie. "Deletion of Phenylalanine-508 in the First Nucleotide Binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization"  J. Biol. Chem. 290, 22862-22878 (2015).
PubMed: 26149808

Assembly members:

Assembly members:
hCFTR_NBD1_delta_RI_F508del, polymer, 228 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET-SUMO hNBD1 deltaRI F508del

Entity Sequences (FASTA):

Entity Sequences (FASTA):
hCFTR_NBD1_delta_RI_F508del: SLTTTEVVMENVTAFWEEGG TPVLKDINFKIERGQLLAVA GSTGAGKTSLLMMIMGELEP SEGKIKHSGRISFCSQFSWI MPGTIKENIIGVSYDEYRYR SVIKACQLEEDISKFAEKDN IVLGEGGITLSGGQRARISL ARAVYKDADLYLLDSPFGYL DVLTEKEIFESCVCKLMANK TRILVTSKMEHLKKADKILI LHEGSSYFYGTFSELQNLQP DFSSKLMG

Data sets:
Data typeCount
13C chemical shifts375
15N chemical shifts186
1H chemical shifts185

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