BMRB Entry 25668

Name: Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region
Published: 2016-04-18

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PDB ID: 2n4h
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR25668
MolProbity Validation Chart

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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution Structure of the Q343R Mutant of TDP-43 Amyloidogenic Core Region

Deposition date:

2015-06-18

Original release date:

2016-04-18

Authors:

Jiang, Lei-Lei; Zhao, Jian; Hu, Hong-Yu

Citation:

Citation: Jiang, Lei-Lei; Zhao, Jian; Yin, Xiao-Fang; He, Wen-Tian; Yang, Hui; Che, Mei-Xia; Hu, Hong-Yu. "Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation" Sci. Rep. 6, 23928-23928 (2016).
PubMed: 27030292

Assembly members:

Assembly members:
entity, polymer, 50 residues, 5236.875 Da.

Natural source:

Natural source: Common Name: human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pHGB

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: MNFGAFSINPAMMAAAQAAL QSSWGMMGMLASRQNQSGPS GNNQNQGNMQ

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	106
15N chemical shifts	42
1H chemical shifts	128

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	entity	1

Entities:

Entity 1, entity 50 residues - 5236.875 Da.

1	MET	ASN	PHE	GLY	ALA	PHE	SER	ILE	ASN	PRO
2	ALA	MET	MET	ALA	ALA	ALA	GLN	ALA	ALA	LEU
3	GLN	SER	SER	TRP	GLY	MET	MET	GLY	MET	LEU
4	ALA	SER	ARG	GLN	ASN	GLN	SER	GLY	PRO	SER
5	GLY	ASN	ASN	GLN	ASN	GLN	GLY	ASN	MET	GLN

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D C(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HNHA	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1

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BMRB Entry 25668

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

1	MET	ASN	PHE	GLY	ALA	PHE	SER	ILE	ASN	PRO
2	ALA	MET	MET	ALA	ALA	ALA	GLN	ALA	ALA	LEU
3	GLN	SER	SER	TRP	GLY	MET	MET	GLY	MET	LEU
4	ALA	SER	ARG	GLN	ASN	GLN	SER	GLY	PRO	SER
5	GLY	ASN	ASN	GLN	ASN	GLN	GLY	ASN	MET	GLN

1	MET	ASN	PHE	GLY	ALA	PHE	SER	ILE	ASN	PRO
2	ALA	MET	MET	ALA	ALA	ALA	GLN	ALA	ALA	LEU
3	GLN	SER	SER	TRP	GLY	MET	MET	GLY	MET	LEU
4	ALA	SER	ARG	GLN	ASN	GLN	SER	GLY	PRO	SER
5	GLY	ASN	ASN	GLN	ASN	GLN	GLY	ASN	MET	GLN

1	MET	ASN	PHE	GLY	ALA	PHE	SER	ILE	ASN	PRO
2	ALA	MET	MET	ALA	ALA	ALA	GLN	ALA	ALA	LEU
3	GLN	SER	SER	TRP	GLY	MET	MET	GLY	MET	LEU
4	ALA	SER	ARG	GLN	ASN	GLN	SER	GLY	PRO	SER
5	GLY	ASN	ASN	GLN	ASN	GLN	GLY	ASN	MET	GLN