BMRB Entry 25659

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PDB ID: 2n3x
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR25659
MolProbity Validation Chart

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Title:
Solution Structure of TDP-43 Amyloidogenic Core Region
Deposition date:
2015-06-11
Original release date:
2016-04-18
Authors:
Jiang, Lei-Lei; Zhao, Jian; Zhou, Chen-Jie; Hu, Hong-Yu
Citation:

Citation: Jiang, Lei-Lei; Zhao, Jian; Yin, Xiao-Fang; He, Wen-Tian; Yang, Hui; Che, Mei-Xia; Hu, Hong-Yu. "Two mutations G335D and Q343R within the amyloidogenic core region of TDP-43 influence its aggregation and inclusion formation"  Sci. Rep. 6, 23928-23928 (2016).
PubMed: 27030292

Assembly members:

Assembly members:
entity, polymer, 50 residues, 5207.811 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pHGB

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: MNFGAFSINPAMMAAAQAAL QSSWGMMGMLASQQNQSGPS GNNQNQGNMQ

Data sets:
Data typeCount
13C chemical shifts144
15N chemical shifts46
1H chemical shifts155

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 50 residues - 5207.811 Da.

1   METASNPHEGLYALAPHESERILEASNPRO
2   ALAMETMETALAALAALAGLNALAALALEU
3   GLNSERSERTRPGLYMETMETGLYMETLEU
4   ALASERGLNGLNASNGLNSERGLYPROSER
5   GLYASNASNGLNASNGLNGLYASNMETGLN

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