BMRB Entry 25274

Name: Solution structure of cytosolic part of Trop2
Published: 2015-05-04

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PDB ID: 2mvl
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, SPARTA
BMRB Entry DOI: doi:10.13018/BMR25274
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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of cytosolic part of Trop2

Deposition date:

2014-10-08

Original release date:

2015-05-04

Authors:

Ilc, Gregor; Plavec, Janez; Vidmar, Tilen; Pavsic, Miha; Lenarcic, Brigita

Citation:

Citation: Ilc, Gregor; Lenarcic, Brigita; Plavec, Janez; Vidmar, Tilen; Pavsic, Miha. "A Structural View of the Trop2-Mediated Signaling Mechanism Revealed by NMR and Molecular Dynamics" .

Assembly members:

Assembly members:
entity, polymer, 26 residues, 3096.678 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: TNRRKSGKYKKVEIKELGEL RKEPSL

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	74
15N chemical shifts	21
1H chemical shifts	186

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	entity	1

Entities:

Entity 1, entity 26 residues - 3096.678 Da.

1

THR

ASN

ARG

LYS

SER

GLY

LYS

TYR

LYS

2

LYS

VAL

GLU

ILE

LYS

GLU

LEU

GLY

GLU

LEU

3

ARG

LYS

GLU

PRO

SER

LEU

Samples:

sample_1: TropIC 5 mM; Trifluoroethanol; H2O

sample_conditions_1: ionic strength: 0 M; pH: 7.4; pressure: 1 atm; temperature: 273 K

Experiments:

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-1H TOCSY	sample_1	isotropic	sample_conditions_1
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1

Software:

CYANA, Guntert, Mumenthaler and Wuthrich - structure solution

NMR spectrometers:

Varian VNMRS 800 MHz

BMRB	19342
PDB	2MVL
EMBL	CAA31781 CAA54799 CAA54801 CAG47056
GB	AAA52505 AAH09409 AAP35919 AAP88905 AAX29730
REF	NP_002344 XP_002810812 XP_003265191 XP_003824268 XP_003892008
SP	P09758
AlphaFold	P09758