BMRB Entry 19560
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR19560
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NMR-STAR v3 text file.
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Citation: Dyson, H. Jane; Park, Sung Jean; Martinez-Yamout, Maria. "The client protein p53 forms a molten globule-like state in the presence of Hsp90" Nat. Struct. Biol. 18, 537-542 (2011).
PubMed: 21460846
Assembly members:
Hsp90_N_domain, polymer, 221 residues, Formula weight is not available
Hsp90_M_domain, polymer, 261 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET21
Entity Sequences (FASTA):
Hsp90_N_domain: GHVETFAFQAEIAQLMSLII
NTFYSNKEIFLRELISNSSD
ALDKIRYETLTDPSKLDSGK
ELHINLIPNKQDRTLTIVDT
GIGMTKADLINNLGTIAKSG
TKAFMEALQAGADISMIGQF
GVGFYSAYLVAEKVTVITKH
NDDEQYAWESSAGGSFTVRT
DTGEPMGRGTKVILHLKEDQ
TEYLEERRIKEIVKKHSQFI
GYPITLFVEKERDKEVSDDE
A
Hsp90_M_domain: KPIWTRNPDDITNEEYGEFY
KSLTNDWEDHLAVKHFSVEG
QLEFRALLFVPRRAPFDLFE
NRKKKNNIKLYVRRVFIMDN
CEELIPEYLNFIRGVVDSED
LPLNISREMLQQSKILKVIR
KNLVKKCLELFTELAEDKEN
YKKFYEQFSKNIKLGIHEDS
QNRKKLSELLRYYTSASGDE
MVSLKDYCTRMKENQKHIYY
ITGETKDQVANSAFVERLRK
HGLEVIYMIEPIDEYCVQQL
KEFEGKTLVSVTKEGLELPE
D
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 1181 |
| 15N chemical shifts | 404 |
| 1H chemical shifts | 404 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | N-terminal domain | 1 |
| 2 | Middle domain | 2 |
Entities:
Entity 1, N-terminal domain 221 residues - Formula weight is not available
| 1 | GLY | HIS | VAL | GLU | THR | PHE | ALA | PHE | GLN | ALA | ||||
| 2 | GLU | ILE | ALA | GLN | LEU | MET | SER | LEU | ILE | ILE | ||||
| 3 | ASN | THR | PHE | TYR | SER | ASN | LYS | GLU | ILE | PHE | ||||
| 4 | LEU | ARG | GLU | LEU | ILE | SER | ASN | SER | SER | ASP | ||||
| 5 | ALA | LEU | ASP | LYS | ILE | ARG | TYR | GLU | THR | LEU | ||||
| 6 | THR | ASP | PRO | SER | LYS | LEU | ASP | SER | GLY | LYS | ||||
| 7 | GLU | LEU | HIS | ILE | ASN | LEU | ILE | PRO | ASN | LYS | ||||
| 8 | GLN | ASP | ARG | THR | LEU | THR | ILE | VAL | ASP | THR | ||||
| 9 | GLY | ILE | GLY | MET | THR | LYS | ALA | ASP | LEU | ILE | ||||
| 10 | ASN | ASN | LEU | GLY | THR | ILE | ALA | LYS | SER | GLY | ||||
| 11 | THR | LYS | ALA | PHE | MET | GLU | ALA | LEU | GLN | ALA | ||||
| 12 | GLY | ALA | ASP | ILE | SER | MET | ILE | GLY | GLN | PHE | ||||
| 13 | GLY | VAL | GLY | PHE | TYR | SER | ALA | TYR | LEU | VAL | ||||
| 14 | ALA | GLU | LYS | VAL | THR | VAL | ILE | THR | LYS | HIS | ||||
| 15 | ASN | ASP | ASP | GLU | GLN | TYR | ALA | TRP | GLU | SER | ||||
| 16 | SER | ALA | GLY | GLY | SER | PHE | THR | VAL | ARG | THR | ||||
| 17 | ASP | THR | GLY | GLU | PRO | MET | GLY | ARG | GLY | THR | ||||
| 18 | LYS | VAL | ILE | LEU | HIS | LEU | LYS | GLU | ASP | GLN | ||||
| 19 | THR | GLU | TYR | LEU | GLU | GLU | ARG | ARG | ILE | LYS | ||||
| 20 | GLU | ILE | VAL | LYS | LYS | HIS | SER | GLN | PHE | ILE | ||||
| 21 | GLY | TYR | PRO | ILE | THR | LEU | PHE | VAL | GLU | LYS | ||||
| 22 | GLU | ARG | ASP | LYS | GLU | VAL | SER | ASP | ASP | GLU | ||||
| 23 | ALA |
Entity 2, Middle domain 261 residues - Formula weight is not available
| 1 | LYS | PRO | ILE | TRP | THR | ARG | ASN | PRO | ASP | ASP | ||||
| 2 | ILE | THR | ASN | GLU | GLU | TYR | GLY | GLU | PHE | TYR | ||||
| 3 | LYS | SER | LEU | THR | ASN | ASP | TRP | GLU | ASP | HIS | ||||
| 4 | LEU | ALA | VAL | LYS | HIS | PHE | SER | VAL | GLU | GLY | ||||
| 5 | GLN | LEU | GLU | PHE | ARG | ALA | LEU | LEU | PHE | VAL | ||||
| 6 | PRO | ARG | ARG | ALA | PRO | PHE | ASP | LEU | PHE | GLU | ||||
| 7 | ASN | ARG | LYS | LYS | LYS | ASN | ASN | ILE | LYS | LEU | ||||
| 8 | TYR | VAL | ARG | ARG | VAL | PHE | ILE | MET | ASP | ASN | ||||
| 9 | CYS | GLU | GLU | LEU | ILE | PRO | GLU | TYR | LEU | ASN | ||||
| 10 | PHE | ILE | ARG | GLY | VAL | VAL | ASP | SER | GLU | ASP | ||||
| 11 | LEU | PRO | LEU | ASN | ILE | SER | ARG | GLU | MET | LEU | ||||
| 12 | GLN | GLN | SER | LYS | ILE | LEU | LYS | VAL | ILE | ARG | ||||
| 13 | LYS | ASN | LEU | VAL | LYS | LYS | CYS | LEU | GLU | LEU | ||||
| 14 | PHE | THR | GLU | LEU | ALA | GLU | ASP | LYS | GLU | ASN | ||||
| 15 | TYR | LYS | LYS | PHE | TYR | GLU | GLN | PHE | SER | LYS | ||||
| 16 | ASN | ILE | LYS | LEU | GLY | ILE | HIS | GLU | ASP | SER | ||||
| 17 | GLN | ASN | ARG | LYS | LYS | LEU | SER | GLU | LEU | LEU | ||||
| 18 | ARG | TYR | TYR | THR | SER | ALA | SER | GLY | ASP | GLU | ||||
| 19 | MET | VAL | SER | LEU | LYS | ASP | TYR | CYS | THR | ARG | ||||
| 20 | MET | LYS | GLU | ASN | GLN | LYS | HIS | ILE | TYR | TYR | ||||
| 21 | ILE | THR | GLY | GLU | THR | LYS | ASP | GLN | VAL | ALA | ||||
| 22 | ASN | SER | ALA | PHE | VAL | GLU | ARG | LEU | ARG | LYS | ||||
| 23 | HIS | GLY | LEU | GLU | VAL | ILE | TYR | MET | ILE | GLU | ||||
| 24 | PRO | ILE | ASP | GLU | TYR | CYS | VAL | GLN | GLN | LEU | ||||
| 25 | LYS | GLU | PHE | GLU | GLY | LYS | THR | LEU | VAL | SER | ||||
| 26 | VAL | THR | LYS | GLU | GLY | LEU | GLU | LEU | PRO | GLU | ||||
| 27 | ASP |
Related Database Links:
Download HSQC peak lists in one of the following formats:
CSV: Backbone
or all simulated peaks
SPARKY: Backbone
or all simulated peaks