BMRB Entry 19240

Name: Human FKBP12-Major Form
Published: 2013-07-15

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR19240

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Human FKBP12-Major Form

Deposition date:

2013-05-14

Original release date:

2013-07-15

Authors:

Mustafi, Sourajit; Chen, Hui; Li, Hongmin; LeMaster, David; Hernandez, Griselda

Citation:

Citation: Mustafi, Sourajit; Chen, Hui; Li, Hongmin; Lemaster, David; Hernandez, Griselda. "Analyzing the visible conformational substates of the FK506-binding protein FKBP12." Biochem. J. 453, 371-380 (2013).
PubMed: 23688288

Assembly members:

Assembly members:
FKBP12, polymer, 107 residues, 11819.5 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET11a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
FKBP12: GVQVETISPGDGRTFPKRGQ TCVVHYTGMLEDGKKFDSSR DRNKPFKFMLGKQEVIRGWE EGVAQMSVGQRAKLTISPDY AYGATGHPGIIPPHATLVFD VELLKLE

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	479
15N chemical shifts	105
1H chemical shifts	737

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	FKBP12	1

Entities:

Entity 1, FKBP12 107 residues - 11819.5 Da.

1

GLY

VAL

GLN

VAL

GLU

THR

ILE

SER

PRO

GLY

2

ASP

GLY

ARG

THR

PHE

PRO

LYS

ARG

GLY

GLN

3

THR

CYS

VAL

HIS

TYR

THR

GLY

MET

LEU

4

GLU

ASP

GLY

LYS

PHE

ASP

SER

ARG

5

ASP

ARG

ASN

LYS

PRO

PHE

LYS

PHE

MET

LEU

6

GLY

LYS

GLN

GLU

VAL

ILE

ARG

GLY

TRP

GLU

7

GLU

GLY

VAL

ALA

GLN

MET

SER

VAL

GLY

GLN

8

ARG

ALA

LYS

LEU

THR

ILE

SER

PRO

ASP

TYR

9

ALA

TYR

GLY

ALA

THR

GLY

HIS

PRO

GLY

ILE

10

ILE

PRO

HIS

ALA

THR

LEU

VAL

PHE

ASP

11

VAL

GLU

LEU

LYS

LEU

GLU

Name	Sample	Sample state	Sample conditions
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HCACO	sample_1	isotropic	sample_conditions_1
3D H(CCO)NH	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aliphatic	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC aromatic	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_2	isotropic	sample_condition_2
2D DQF-COSY	sample_2	isotropic	sample_condition_2

Related Database Links:

BMRB	16931 11471 16925 16931 16933 19241
PDB	1A7X 1B6C 1BKF 1BL4 1D6O 1D7H 1D7I 1D7J 1EYM 1F40 1FAP 1FKB 1FKD 1FKF 1FKG 1FKH 1FKI 1FKJ 1FKK 1FKL 1FKR 1FKS 1FKT 1J4H 1J4I 1J4R 1NSG 1QPF 1QPL 1TCO 2DG3 2DG4 2DG9 2FAP 2FKE 2PPN 2PPO 2PPP 2RSE 3FAP 3H9R 3MDY 4DH0 4FAP 4IPX 4N19
DBJ	BAB22351 BAB27125 BAB31680 BAE32804 BAE40271
EMBL	CAA36462 CAA39272 CAA42762 CAG28541 CAG46965
GB	AAA19163 AAA31252 AAA35844 AAA58472 AAA58476
PRF	1613455A
REF	NP_000792 NP_001030533 NP_001033089 NP_001164597 NP_001239119
SP	P18203 P26883 P62942 P62943 Q62658
TPG	DAA23300
AlphaFold	P18203 P26883 P62942 P62943 Q62658

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks

BMRB Entry 19240

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links: