BMRB Entry 19203

Name: NMR structure of RNA recognition motif 2 (RRM2) of Homo sapiens splicing factor, arginine/serine-rich 1
Published: 2013-05-13

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PDB ID: 2m7s
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19203
MolProbity Validation Chart

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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR structure of RNA recognition motif 2 (RRM2) of Homo sapiens splicing factor, arginine/serine-rich 1

Deposition date:

2013-04-29

Original release date:

2013-05-13

Authors:

Dutta, Samit; Serrano, Pedro; Geralt, Michael; Wuthrich, Kurt

Citation:

Citation: Dutta, Samit; Serrano, Pedro; Geralt, Michael; Wuthrich, Kurt. "NMR structure of RNA recognition motif 2 (RRM2) of Homo sapiens splicing factor, arginine/serine-rich 1" .

Assembly members:

Assembly members:
RRM2, polymer, 90 residues, 10207.483 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: SpeedET

Entity Sequences (FASTA):

Entity Sequences (FASTA):
RRM2: GAPRGRYGPPSRRSENRVVV SGLPPSGSWQDLKDHMREAG DVCYADVYRDGTGVVEFVRK EDMTYAVRKLDNTKFRSHEG ETAYIRVKVD

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	281
15N chemical shifts	87
1H chemical shifts	593

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	RRM2 of Homo sapiens splicing factor, arginine/serine-rich 1	1

Entities:

Entity 1, RRM2 of Homo sapiens splicing factor, arginine/serine-rich 1 90 residues - 10207.483 Da.

1	GLY	ALA	PRO	ARG	GLY	ARG	TYR	GLY	PRO	PRO
2	SER	ARG	ARG	SER	GLU	ASN	ARG	VAL	VAL	VAL
3	SER	GLY	LEU	PRO	PRO	SER	GLY	SER	TRP	GLN
4	ASP	LEU	LYS	ASP	HIS	MET	ARG	GLU	ALA	GLY
5	ASP	VAL	CYS	TYR	ALA	ASP	VAL	TYR	ARG	ASP
6	GLY	THR	GLY	VAL	VAL	GLU	PHE	VAL	ARG	LYS
7	GLU	ASP	MET	THR	TYR	ALA	VAL	ARG	LYS	LEU
8	ASP	ASN	THR	LYS	PHE	ARG	SER	HIS	GLU	GLY
9	GLU	THR	ALA	TYR	ILE	ARG	VAL	LYS	VAL	ASP

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
4D-HACANH-APSY	sample_1	isotropic	sample_conditions_1
5D-CBCACONH-APSY	sample_1	isotropic	sample_conditions_1
5D-HACACONH-APSY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic with non-uniform sampling	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic with non-uniform sampling	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY with non-uniform sampling	sample_1	isotropic	sample_conditions_1

BMRB	19248
PDB	1X4C 2M7S 2M8D 2O3D 3BEG 4C0O
DBJ	BAB93456 BAC37367 BAE29641 BAE88160 BAF82622
EMBL	CAH92288
GB	AAA03476 AAA35564 AAA35565 AAH10264 AAH42354
REF	NP_001006919 NP_001033096 NP_001069862 NP_001071635 NP_001103022
SP	Q07955 Q0VCY7 Q3YLA6 Q5R7H2 Q6DII2
TPG	DAA19172
AlphaFold	Q07955 Q0VCY7 Q3YLA6 Q5R7H2 Q6DII2

BMRB Entry 19203

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	ALA	PRO	ARG	GLY	ARG	TYR	GLY	PRO	PRO
2	SER	ARG	ARG	SER	GLU	ASN	ARG	VAL	VAL	VAL
3	SER	GLY	LEU	PRO	PRO	SER	GLY	SER	TRP	GLN
4	ASP	LEU	LYS	ASP	HIS	MET	ARG	GLU	ALA	GLY
5	ASP	VAL	CYS	TYR	ALA	ASP	VAL	TYR	ARG	ASP
6	GLY	THR	GLY	VAL	VAL	GLU	PHE	VAL	ARG	LYS
7	GLU	ASP	MET	THR	TYR	ALA	VAL	ARG	LYS	LEU
8	ASP	ASN	THR	LYS	PHE	ARG	SER	HIS	GLU	GLY
9	GLU	THR	ALA	TYR	ILE	ARG	VAL	LYS	VAL	ASP

1	GLY	ALA	PRO	ARG	GLY	ARG	TYR	GLY	PRO	PRO
2	SER	ARG	ARG	SER	GLU	ASN	ARG	VAL	VAL	VAL
3	SER	GLY	LEU	PRO	PRO	SER	GLY	SER	TRP	GLN
4	ASP	LEU	LYS	ASP	HIS	MET	ARG	GLU	ALA	GLY
5	ASP	VAL	CYS	TYR	ALA	ASP	VAL	TYR	ARG	ASP
6	GLY	THR	GLY	VAL	VAL	GLU	PHE	VAL	ARG	LYS
7	GLU	ASP	MET	THR	TYR	ALA	VAL	ARG	LYS	LEU
8	ASP	ASN	THR	LYS	PHE	ARG	SER	HIS	GLU	GLY
9	GLU	THR	ALA	TYR	ILE	ARG	VAL	LYS	VAL	ASP

1	GLY	ALA	PRO	ARG	GLY	ARG	TYR	GLY	PRO	PRO
2	SER	ARG	ARG	SER	GLU	ASN	ARG	VAL	VAL	VAL
3	SER	GLY	LEU	PRO	PRO	SER	GLY	SER	TRP	GLN
4	ASP	LEU	LYS	ASP	HIS	MET	ARG	GLU	ALA	GLY
5	ASP	VAL	CYS	TYR	ALA	ASP	VAL	TYR	ARG	ASP
6	GLY	THR	GLY	VAL	VAL	GLU	PHE	VAL	ARG	LYS
7	GLU	ASP	MET	THR	TYR	ALA	VAL	ARG	LYS	LEU
8	ASP	ASN	THR	LYS	PHE	ARG	SER	HIS	GLU	GLY
9	GLU	THR	ALA	TYR	ILE	ARG	VAL	LYS	VAL	ASP