BMRB Entry 18599

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PDB ID: 4b2s
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR18599
MolProbity Validation Chart

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Title:
Solution structure of CCP modules 11-12 of complement factor H
Deposition date:
2012-07-18
Original release date:
2012-10-18
Authors:
Makou, Elisavet; Mertens, Haydyn; Maciejewski, Mateusz; Soares, Dinesh; Matis, Ilias; Schmidt, Christoph; Herbert, Andrew; Svergun, Dmitri; Barlow, Paul; Herbert, C
Citation:

Citation: Makou, Elisavet; Mertens, Haydyn; Maciejewski, Mateusz; Soares, Dinesh; Matis, Ilias; Schmidt, Christoph; Herbert, Andrew; Svergun, Dmitri; Barlow, Paul. "Solution structure of CCP modules 10-12 illuminates functional architecture of the complement regulator, factor H."  J. Mol. Biol. 424, 295-312 (2012).
PubMed: 23017427

Assembly members:

Assembly members:
FH11-12, polymer, 127 residues, 14085.6893 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: KOMAGATAELLA PASTORIS   Vector: pPICZaB

Entity Sequences (FASTA):

Entity Sequences (FASTA):
FH11-12: EAEAAGVQSCGPPPELLNGN VKEKTKEEYGHSEVVEYYCN PRFLMKGPNKIQCVDGEWTT LPVCIVEESTCGDIPELEHG WAQLSSPPYYYGDSVEFNCS ESFTMIGHRSITCIHGVWTQ LPQCVAI

Data sets:
Data typeCount
13C chemical shifts550
15N chemical shifts125
1H chemical shifts839

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1FH11-121

Entities:

Entity 1, FH11-12 127 residues - 14085.6893 Da.

1   GLUALAGLUALAALAGLYVALGLNSERCYS
2   GLYPROPROPROGLULEULEUASNGLYASN
3   VALLYSGLULYSTHRLYSGLUGLUTYRGLY
4   HISSERGLUVALVALGLUTYRTYRCYSASN
5   PROARGPHELEUMETLYSGLYPROASNLYS
6   ILEGLNCYSVALASPGLYGLUTRPTHRTHR
7   LEUPROVALCYSILEVALGLUGLUSERTHR
8   CYSGLYASPILEPROGLULEUGLUHISGLY
9   TRPALAGLNLEUSERSERPROPROTYRTYR
10   TYRGLYASPSERVALGLUPHEASNCYSSER
11   GLUSERPHETHRMETILEGLYHISARGSER
12   ILETHRCYSILEHISGLYVALTRPTHRGLN
13   LEUPROGLNCYSVALALAILE

Related Database Links:

UniProt CFAH_HUMAN
PDB 4B2S
AlphaFold Q9NU86

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