BMRB Entry 17977
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17977
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NMR-STAR v3 text file.
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Citation: Hughes, Travis; Chalmers, Michael; Novick, Scott; Kuruvilla, Dana; Chang, Mi Ra; Kamenecka, Theodore; Rance, Mark; Johnson, Bruce; Burris, Thomas; Griffin, Patrick; Kojetin, Douglas. "Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPAR Agonism." Structure 20, 139-150 (2012).
PubMed: 22244763
Assembly members:
PPARgamma_LBD, polymer, 276 residues, Formula weight is not available
240, non-polymer, 527.488 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET-46
Entity Sequences (FASTA):
PPARgamma_LBD: GQLNPESADLRALAKHLYDS
YIKSFPLTKAKARAILTGKT
TDKSPFVIYDMNSLMMGEDK
IKFKHITPLQEQSKEVAIRI
FQGCQFRSVEAVQEITEYAK
SIPGFVNLDLNDQVTLLKYG
VHEIIYTMLASLMNKDGVLI
SEGQGFMTREFLKSLRKPFG
DFMEPKFEFAVKFNALELDD
SDLAIFIAVIILSGDRPGLL
NVKPIEDIQDNLLQALELQL
KLNHPESSQLFAKLLQKMTD
LRQIVTEHVQLLQVIKKTET
DMSLHPLLQEIYKDLY
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 499 |
| 15N chemical shifts | 169 |
| 1H chemical shifts | 170 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | PPARgamma_LBD | 1 |
| 2 | MRL20 | 2 |
Entities:
Entity 1, PPARgamma_LBD 276 residues - Formula weight is not available
| 1 | GLY | GLN | LEU | ASN | PRO | GLU | SER | ALA | ASP | LEU | ||||
| 2 | ARG | ALA | LEU | ALA | LYS | HIS | LEU | TYR | ASP | SER | ||||
| 3 | TYR | ILE | LYS | SER | PHE | PRO | LEU | THR | LYS | ALA | ||||
| 4 | LYS | ALA | ARG | ALA | ILE | LEU | THR | GLY | LYS | THR | ||||
| 5 | THR | ASP | LYS | SER | PRO | PHE | VAL | ILE | TYR | ASP | ||||
| 6 | MET | ASN | SER | LEU | MET | MET | GLY | GLU | ASP | LYS | ||||
| 7 | ILE | LYS | PHE | LYS | HIS | ILE | THR | PRO | LEU | GLN | ||||
| 8 | GLU | GLN | SER | LYS | GLU | VAL | ALA | ILE | ARG | ILE | ||||
| 9 | PHE | GLN | GLY | CYS | GLN | PHE | ARG | SER | VAL | GLU | ||||
| 10 | ALA | VAL | GLN | GLU | ILE | THR | GLU | TYR | ALA | LYS | ||||
| 11 | SER | ILE | PRO | GLY | PHE | VAL | ASN | LEU | ASP | LEU | ||||
| 12 | ASN | ASP | GLN | VAL | THR | LEU | LEU | LYS | TYR | GLY | ||||
| 13 | VAL | HIS | GLU | ILE | ILE | TYR | THR | MET | LEU | ALA | ||||
| 14 | SER | LEU | MET | ASN | LYS | ASP | GLY | VAL | LEU | ILE | ||||
| 15 | SER | GLU | GLY | GLN | GLY | PHE | MET | THR | ARG | GLU | ||||
| 16 | PHE | LEU | LYS | SER | LEU | ARG | LYS | PRO | PHE | GLY | ||||
| 17 | ASP | PHE | MET | GLU | PRO | LYS | PHE | GLU | PHE | ALA | ||||
| 18 | VAL | LYS | PHE | ASN | ALA | LEU | GLU | LEU | ASP | ASP | ||||
| 19 | SER | ASP | LEU | ALA | ILE | PHE | ILE | ALA | VAL | ILE | ||||
| 20 | ILE | LEU | SER | GLY | ASP | ARG | PRO | GLY | LEU | LEU | ||||
| 21 | ASN | VAL | LYS | PRO | ILE | GLU | ASP | ILE | GLN | ASP | ||||
| 22 | ASN | LEU | LEU | GLN | ALA | LEU | GLU | LEU | GLN | LEU | ||||
| 23 | LYS | LEU | ASN | HIS | PRO | GLU | SER | SER | GLN | LEU | ||||
| 24 | PHE | ALA | LYS | LEU | LEU | GLN | LYS | MET | THR | ASP | ||||
| 25 | LEU | ARG | GLN | ILE | VAL | THR | GLU | HIS | VAL | GLN | ||||
| 26 | LEU | LEU | GLN | VAL | ILE | LYS | LYS | THR | GLU | THR | ||||
| 27 | ASP | MET | SER | LEU | HIS | PRO | LEU | LEU | GLN | GLU | ||||
| 28 | ILE | TYR | LYS | ASP | LEU | TYR |
Entity 2, MRL20 - C28 H24 F3 N O6 - 527.488 Da.
| 1 | 240 |
Related Database Links:
Download HSQC peak lists in one of the following formats:
CSV: Backbone
or all simulated peaks
SPARKY: Backbone
or all simulated peaks