BMRB Entry 17929
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PDB ID: 2ljc
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, SPARTA
BMRB Entry DOI: doi:10.13018/BMR17929
MolProbity Validation Chart
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NMR-STAR v3 text file.
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Citation: Pielak, Rafal; Oxenoid, Kirill; Chou, James. "Structural investigation of rimantadine inhibition of the AM2-BM2 chimera channel of influenza viruses" Structure 19, 1655-1663 (2011).
PubMed: 22078564
Assembly members:
AM2-BM2, polymer, 35 residues, 3244.864 Da.
RIM, non-polymer, 179.302 Da.
Natural source: Common Name: Influenzavirus A and B Taxonomy ID: 197911 Superkingdom: Viruses Kingdom: not available Genus/species: Influenzavirus A and B not available
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: trpLE-fusion
Entity Sequences (FASTA):
AM2-BM2: RSNDSSDPLVVAASIIGILH
FIAWTIGHLNQIKRG
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 14 |
| 15N chemical shifts | 24 |
| 1H chemical shifts | 24 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | AM2-BM2_1 | 1 |
| 2 | AM2-BM2_2 | 1 |
| 3 | AM2-BM2_3 | 1 |
| 4 | AM2-BM2_4 | 1 |
| 5 | RIMANTADINE | 2 |
Entities:
Entity 1, AM2-BM2_1 35 residues - 3244.864 Da.
Residues 18-37 is from M2 of influenza A Residues 38-52 correspond to 20-34 from BM2 of influenza B
| 1 | ARG | SER | ASN | ASP | SER | SER | ASP | PRO | LEU | VAL | ||||
| 2 | VAL | ALA | ALA | SER | ILE | ILE | GLY | ILE | LEU | HIS | ||||
| 3 | PHE | ILE | ALA | TRP | THR | ILE | GLY | HIS | LEU | ASN | ||||
| 4 | GLN | ILE | LYS | ARG | GLY |
Entity 2, RIMANTADINE - C12 H21 N - 179.302 Da.
| 1 | RIM |
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