BMRB Entry 17312

Title:
Tah1 complexed by MEEVD
Deposition date:
2010-11-22
Original release date:
2012-01-04
Authors:
Jimenez, Beatriz; Ugwu, Francisca; Zhao, Rongmin; Orti, Leticia; Houry, Walid; Pineda-Lucena, Antonio
Citation:

Citation: Jimenez, Beatriz; Ugwu, Francisca; Zhao, Rongmin; Orti, Leticia; Makhnevych, Taras; Pineda-Lucena, Antonio; Houry, Walid. "Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90."  J. Biol. Chem. 287, 5698-5709 (2012).
PubMed: 22179618

Assembly members:

Assembly members:
Tah1, polymer, 111 residues, 12567 Da.
MEEVD, polymer, 5 residues, 12567 Da.

Natural source:

Natural source:   Common Name: Baker's yeast   Taxonomy ID: 4932   Superkingdom: Eukaryota   Kingdom: Fungi   Genus/species: Saccharomyces cerevisiae

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pRIL

Data sets:
Data typeCount
13C chemical shifts537
15N chemical shifts117
1H chemical shifts839

Additional metadata:

  • Assembly
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  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1molecule 11
2molecule 22

Entities:

Entity 1, molecule 1 111 residues - 12567 Da.

Tah1 is a TPR repeat-containing protein associated with Hsp90

1   METSERGLNPHEGLULYSGLNLYSGLUGLN
2   GLYASNSERLEUPHELYSGLNGLYLEUTYR
3   ARGGLUALAVALHISCYSTYRASPGLNLEU
4   ILETHRALAGLNPROGLNASNPROVALGLY
5   TYRSERASNLYSALAMETALALEUILELYS
6   LEUGLYGLUTYRTHRGLNALAILEGLNMET
7   CYSGLNGLNGLYLEUARGTYRTHRSERTHR
8   ALAGLUHISVALALAILEARGSERLYSLEU
9   GLNTYRARGLEUGLULEUALAGLNGLYALA
10   VALGLYSERVALGLNILEPROVALVALGLU
11   VALASPGLULEUPROGLUGLYTYRASPARG
12   SER

Entity 2, molecule 2 5 residues - 12567 Da.

Pentapeptide: Ac-MEEVD It is the C-terminus part of Hsp90

1   METGLUGLUVALASP

Related Database Links:

UNP P25638
BMRB 18445 18447
PDB 2L6J 2LSU 2LSV 4CGQ 4CGU
DBJ GAA21965
EMBL CAA42288 CAY78265
GB AAS56477 AHN96120 AHV79323 AHY79733 AJP37484
REF NP_009986
SP P25638
TPG DAA07534
AlphaFold D6VR65 P25638

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks