BMRB Entry 17127
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PDB ID: 2l29
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17127
MolProbity Validation Chart
NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
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Citation: Williams, Christopher; Hoppe, Hans; Rezgui, Dellel; Strickland, Madeline; Frago, Susana; Ellis, Rosamund; Wattana-Amorn, Pakorn; Prince, Stuart; Zaccheo, Oliver; Forbes, Briony; Jones, E.; Crump, Matthew; Hassan, A.; Grutzner, Frank; Nolan, Catherine; Mungall, Andrew. "An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution" Science 338, 1209-1213 (2012).
PubMed: 23197533
Assembly members:
HD11, polymer, 142 residues, 15434.610 Da.
IGF2, polymer, 67 residues, 7484.514 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET26a
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 768 |
| 15N chemical shifts | 215 |
| 1H chemical shifts | 1282 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | human domain 11 | 1 |
| 2 | IGF2 | 2 |
Entities:
Entity 1, human domain 11 142 residues - 15434.610 Da.
Mutated Domain 11 of the Cytoplasmic region of the Cation-independent mannose-6-phosphate receptor E4 IGF2R domain 11 in complex with IGF-II
| 1 | MET | LYS | SER | ASN | GLU | HIS | ASP | ASP | CYS | GLN | ||||
| 2 | VAL | THR | ASN | PRO | SER | THR | GLY | HIS | LEU | PHE | ||||
| 3 | ASP | LEU | SER | SER | LEU | SER | GLY | ARG | ALA | GLY | ||||
| 4 | PHE | THR | ALA | ALA | TYR | SER | LYS | SER | GLY | VAL | ||||
| 5 | VAL | TYR | MET | SER | ILE | CYS | GLY | GLU | ASN | GLU | ||||
| 6 | ASN | CYS | PRO | PRO | GLY | VAL | GLY | ALA | CYS | PHE | ||||
| 7 | GLY | GLN | THR | ARG | ILE | SER | VAL | GLY | LYS | ALA | ||||
| 8 | ASN | LYS | ARG | LEU | ARG | TYR | VAL | ASP | GLN | VAL | ||||
| 9 | LEU | GLN | LEU | VAL | TYR | LYS | ASP | GLY | SER | PRO | ||||
| 10 | CYS | PRO | SER | LYS | SER | GLY | LEU | SER | TYR | LYS | ||||
| 11 | SER | VAL | ILE | SER | PHE | VAL | CYS | ARG | PRO | GLU | ||||
| 12 | ALA | GLY | PRO | THR | ASN | ARG | PRO | MET | LEU | ILE | ||||
| 13 | SER | LEU | ASP | LYS | GLN | THR | CYS | THR | LEU | PHE | ||||
| 14 | PHE | SER | TRP | HIS | THR | PRO | LEU | ALA | CYS | GLU | ||||
| 15 | PRO | GLU |
Entity 2, IGF2 67 residues - 7484.514 Da.
| 1 | ALA | TYR | ARG | PRO | SER | GLU | THR | LEU | CYS | GLY | ||||
| 2 | GLY | GLU | LEU | VAL | ASP | THR | LEU | GLN | PHE | VAL | ||||
| 3 | CYS | GLY | ASP | ARG | GLY | PHE | TYR | PHE | SER | ARG | ||||
| 4 | PRO | ALA | SER | ARG | VAL | SER | ARG | ARG | SER | ARG | ||||
| 5 | GLY | ILE | VAL | GLU | GLU | CYS | CYS | PHE | ARG | SER | ||||
| 6 | CYS | ASP | LEU | ALA | LEU | LEU | GLU | THR | TYR | CYS | ||||
| 7 | ALA | THR | PRO | ALA | LYS | SER | GLU |
Related Database Links:
| BMRB | 17128 19117 19153 |
| PDB | 1E6F 1GP0 1GP3 1GQB 2CNJ 2L29 2L2A 2M68 2M6T 1IGL 2V5P 3E4Z 3KR3 |
| DBJ | BAF84283 BAG36657 BAG54360 BAI46830 BAO53964 |
| EMBL | CAA04657 CAA25426 CAA27156 CAA27249 CAA29516 |
| GB | AAA52544 AAA52545 AAA60088 AAA73915 AAB26479 |
| PRF | 0407244A:PDB=1GF2 1009249A 1203258B 1707201B 1904317A |
| REF | NP_000603 NP_001007140 NP_001108011 NP_001121070 NP_001164877 |
| SP | P01344 P23695 P41694 P51459 Q08279 |
| AlphaFold | P01344 P23695 P41694 P51459 Q08279 |
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