BMRB Entry 16694

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PDB ID: 2ktb
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR16694
MolProbity Validation Chart

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Title:
Solution Structure of the Second Bromodomain of Human Polybromo in complex with an acetylated peptide from Histone 3
Deposition date:
2010-01-27
Original release date:
2010-05-05
Authors:
Charlop-Powers, Zachary; Zhang, Qiang; Zeng, Lei
Citation:

Citation: Charlop-Powers, Zachary; Zeng, Lei; Zhang, Qiang; Zhou, Ming-Ming. "Structural insights into selective histone H3 recognition by the human Polybromo bromodomain 2."  Cell Res. 20, 529-538 (2010).
PubMed: 20368734

Assembly members:

Assembly members:
H3_Peptide, polymer, 20 residues, 2061.412 Da.
Polybromo_Bromdomain2, polymer, 121 residues, 13676.851 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: obtained from a vendor

Entity Sequences (FASTA):

Entity Sequences (FASTA):
H3_Peptide: ARTKQTARKSTGGKAPRKQL
Polybromo_Bromdomain2: STEGSSPAYLKEILEQLLEA IVVATNPSGRLISELFQKLP SKVQYPDYYAIIKEPIDLKT IAQRIQNGSYKSIHAMAKDI DLLAKNAKTYNEPGSQVFKD ANSIKKIFYMKKAEIEHHEM A

Data sets:
Data typeCount
13C chemical shifts379
15N chemical shifts113
1H chemical shifts844

Additional metadata:

  • Assembly
  • Samples and Experiments
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  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1H3_Peptide1
2Polybromo_Bromdomain22

Entities:

Entity 1, H3_Peptide 20 residues - 2061.412 Da.

1   ALAARGTHRLYSGLNTHRALAARGLYSSER
2   THRGLYGLYLYSALAPROARGLYSGLNLEU

Entity 2, Polybromo_Bromdomain2 121 residues - 13676.851 Da.

1   SERTHRGLUGLYSERSERPROALATYRLEU
2   LYSGLUILELEUGLUGLNLEULEUGLUALA
3   ILEVALVALALATHRASNPROSERGLYARG
4   LEUILESERGLULEUPHEGLNLYSLEUPRO
5   SERLYSVALGLNTYRPROASPTYRTYRALA
6   ILEILELYSGLUPROILEASPLEULYSTHR
7   ILEALAGLNARGILEGLNASNGLYSERTYR
8   LYSSERILEHISALAMETALALYSASPILE
9   ASPLEULEUALALYSASNALALYSTHRTYR
10   ASNGLUPROGLYSERGLNVALPHELYSASP
11   ALAASNSERILELYSLYSILEPHETYRMET
12   LYSLYSALAGLUILEGLUHISHISGLUMET
13   ALA

Related Database Links:

BMRB 18385
PDB 1EQZ 1F66 1HQ3 1ID3 1KX3 1KX4 1KX5 1M18 1M19 1M1A 1P34 1P3A 1P3B 1P3F 1P3G 1P3I 1P3K 1P3L 1P3M 1P3O 1P3P 1PU9 1S32 1TZY 1U35 1ZBB 1ZLA 2ARO 2CV5 2F8N 2FJ7 2HIO 2IO5 2KFT 2KWK 2NQB 2NZD 2PYO 2YBA 3A1B 3A6N 3AFA 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B6F 3B6G 3C1B 3C1C 3C9K 3KUY 3KXB 3LEL 3LJA 3LZ0 3LZ1 3MGP 3MGQ 3MGR 3MGS 3MNN 3MVD 3O62 3REH 3REI 3REJ 3REK 3REL 3TU4 3UT9 3UTA 3UTB 3W96 3W97 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4J8U 4J8V 4J8W 4J8X 4JJN 4KGC 4KUD 4LD9 4LK9 4QLC 4R8P 4UUZ 4WU8 4WU9 5C3I 2KTB 3HMF 3LJW
DBJ BAA20144 BAA21441 BAA31218 BAA81840 BAA81841
EMBL CAA17819 CAA23780 CAA24375 CAA24647 CAA24952
GB AAA19824 AAA29441 AAA29965 AAA30003 AAA30026
PIR A56580 A56618 A56654 I37460 I48113
PRF 0710252A 0806228A 1202262D 1202289A 1303352A
REF NP_001005101 NP_001005464 NP_001013074 NP_001013721 NP_001014411 XP_008563175
SP A1CP80 A1D240 A2QRR5 A2XHJ3 A2Y533
TPE CBF88887 CEL66806 CEL70515 CEL74279 CEL78184
TPG DAA07131 DAA10514 DAA16173 DAA16175 DAA16178
UNP Q86U86
AlphaFold A1CP80 A1D240 A2QRR5 A2XHJ3 A2Y533 Q9H314

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