BMRB Entry 15633

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PDB ID: 2k01
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR15633
MolProbity Validation Chart

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Title:
Structure of a locked SDF1 dimer
Deposition date:
2008-01-23
Original release date:
2008-11-06
Authors:
Volkman, B.; Veldkamp, C.; Peterson, F.
Citation:

Citation: Veldkamp, Christopher; Seibert, Christoph; Peterson, Francis; De la Cruz, Noberto; Haugner, John; Basnet, Harihar; Sakmar, Thomas; Volkman, Brian. "Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12"  Sci. Signal. 1, ra4-ra4 (2008).
PubMed: 18799424

Assembly members:

Assembly members:
CXCL12/SDF1-alpha, polymer, 70 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: not available   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pQE30-6HT

Entity Sequences (FASTA):

Entity Sequences (FASTA):
CXCL12/SDF1-alpha: GMKPVSLSYRCPCRFFESHV ARANVKHLKILNTPNCACQI VARLKNNNRQVCIDPKLKWI QEYLEKCLNK

Data sets:
Data typeCount
13C chemical shifts554
15N chemical shifts132
1H chemical shifts933

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1CXCL12/SDF1-alpha_11
2CXCL12/SDF1-alpha_21

Entities:

Entity 1, CXCL12/SDF1-alpha_1 70 residues - Formula weight is not available

The GM dipeptide on the front is a cleavage artifact and should be labeled as residues -1 and 0.

1   GLYMETLYSPROVALSERLEUSERTYRARG
2   CYSPROCYSARGPHEPHEGLUSERHISVAL
3   ALAARGALAASNVALLYSHISLEULYSILE
4   LEUASNTHRPROASNCYSALACYSGLNILE
5   VALALAARGLEULYSASNASNASNARGGLN
6   VALCYSILEASPPROLYSLEULYSTRPILE
7   GLNGLUTYRLEUGLULYSCYSLEUASNLYS

Related Database Links:

BMRB 15635 15636 15637 16142 16143
PDB 1QG7 1SDF 2J7Z 2K01 2K03 2K04 2K05 2KEC 2KED 2SDF 3HP3 4UAI
DBJ BAA28601 BAA28602 BAF85317 BAG11056 BAG34757
EMBL CAG29279
GB AAA97434 AAB39332 AAB39333 AAB40516 AAH39893
REF NP_000600 NP_001009847 NP_001028106 NP_001029058 NP_001171605
SP O62657 P48061
AlphaFold O62657 P48061

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