BMRB Entry 15306

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PDB ID: 2jqz
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR15306
MolProbity Validation Chart

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Title:
Solution Structure of the C2 domain of human Smurf2
Deposition date:
2007-06-15
Original release date:
2008-02-28
Authors:
Wiesner, Silke; Ogunjimi, Abiodun; Wang, Hong-Rui; Rotin, Daniela; Sicheri, Frank; Wrana, Jeff; Forman-Kay, Julie
Citation:

Citation: Wiesner, Silke; Ogunjimi, Abiodun; Wang, Hong-Rui; Rotin, Daniela; Sicheri, Frank; Wrana, Jeff; Forman-Kay, Julie. "Auto-inhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain"  Cell 130, 651-662 (2007).
PubMed: 17719543

Assembly members:

Assembly members:
C2 domain of Smurf2, polymer, 131 residues, 14707.108 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: modified pET24d

Entity Sequences (FASTA):

Entity Sequences (FASTA):
C2 domain of Smurf2: GPVKLRLTVLCAKNLVKKDF FRLPDPFAKVVVDGSGQCHS TDTVKNTLDPKWNQHYDLYI GKSDSVTISVWNHKKIHKKQ GAGFLGCVRLLSNAINRLKD TGYQRLDLCKLGPNDNDTVR GQIVVSLQSRD

Data sets:
Data typeCount
13C chemical shifts433
15N chemical shifts138
1H chemical shifts864

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1C2 domain of Smurf21

Entities:

Entity 1, C2 domain of Smurf2 131 residues - 14707.108 Da.

1   GLYPROVALLYSLEUARGLEUTHRVALLEU
2   CYSALALYSASNLEUVALLYSLYSASPPHE
3   PHEARGLEUPROASPPROPHEALALYSVAL
4   VALVALASPGLYSERGLYGLNCYSHISSER
5   THRASPTHRVALLYSASNTHRLEUASPPRO
6   LYSTRPASNGLNHISTYRASPLEUTYRILE
7   GLYLYSSERASPSERVALTHRILESERVAL
8   TRPASNHISLYSLYSILEHISLYSLYSGLN
9   GLYALAGLYPHELEUGLYCYSVALARGLEU
10   LEUSERASNALAILEASNARGLEULYSASP
11   THRGLYTYRGLNARGLEUASPLEUCYSLYS
12   LEUGLYPROASNASPASNASPTHRVALARG
13   GLYGLNILEVALVALSERLEUGLNSERARG
14   ASP

Related Database Links:

PDB 2JQZ
DBJ BAG11417
EMBL CDQ73842
GB AAG25641 AAG45422 AAG50421 AAG50422 AAH93876
REF NP_001082282 NP_001100531 NP_073576 NP_079757 XP_002186702
SP A2A5Z6 Q2TAS2 Q9HAU4
TPG DAA18293
AlphaFold A2A5Z6 Q2TAS2 Q9HAU4

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